The Texas A&M University System

Mitsubishi Tanabe Pharma Corporation

Robyn Richardson

Roland A Newman

Jeffrey W Smith

Daniel Romo

Julia Coronella

Anjuli Timmer

Sung Wook Cho

Presented herein, in certain embodiments, are compositions comprising binding agents that specifically bind to syndecan-1 and uses thereof.

Syndecan-1 (CD138) binding agents and uses thereof

Derivatives of belactosin and their synthesis are disclosed. In certain embodiments, compounds of the present invention exhibit anti-cancer, antiviral, antibiotic, and/or auto-immune therapeutic abilities. In general, methods of synthesis disclosed herein allow for introduction of a variety of substituents at numerous positions as well as the facile introduction of a beta-lactone ring moiety. The synthetic steps comprise, in preferred embodiments, a tandem Mukaiyama aldol lactonization reaction. Data demonstrating the utility of some of the derivatives as proteasome inhibitors is also disclosed.

Belactosin derivatives as therapeutic agents/biological probes and their synthesis

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San Diego, CA, United States of America

Robyn Richardson