Redwood Bioscience, Inc.

R.p.scherer Technologies, Inc.

Redwiid Bioscience, Inc.

Robyn M Barfield

David Rabuka

Aaron Edward Albers

Romas Alvydas Kudirka

Gregory W deHart

Penelope M Drake

Jesse M McFarland

Albert W Garofalo

Mark Alan Breidenbach

Gregory W Dehart

Maxine Bauzon

Yun Cheol Kim

Ayodele O Ogunkoya

Jesse M Mcfarland

The present disclosure provides anti-CD22 antibody-maytansine conjugate structures. The disclosure also encompasses methods of production of such conjugates, as well as methods of using the same.

Anti-CD22 antibody-maytansine conjugates and methods of use thereof

The present disclosure provides anti-HER2 antibody-maytansine conjugate structures. The disclosure also encompasses methods of production of such conjugates, as well as methods of using the same.

Anti-HER2 antibody-maytansine conjugates and methods of use thereof

The present disclosure provides antibodies specific for Mucin 1. Nucleic acids that encode one or both of the variable chains of an antibody of the present disclosure are also provided, as are cells that include such nucleic acids. Also provided are compositions that include the antibodies of the present disclosure, including in some instances, pharmaceutical compositions. Methods of making and using the antibodies of the present disclosure are also provided. In certain aspects, provided are methods that include administering to an individual having a cell proliferative disorder a therapeutically effective amount of an antibody of the present disclosure, where the antibody is administered to the individual to enhance an immune response, e.g., a T cell response, to abnormally proliferating cells of the cell proliferative disorder. The antibodies are also useful in various diagnostic, and monitoring applications, which are also provided.

Antibody specific for Mucin-1 and methods of use thereof

The present disclosure provides conjugate structures (e.g., polypeptide conjugates) and hydrazinyl-indole compounds used to produce these conjugates. The disclosure also provides methods of production of such conjugates, as well as methods of using the same.

Hydrazinyl-indole compounds and methods for producing a conjugate

The present disclosure provides aldehyde-tagged immunoglobulin (Ig) polypeptides that can be converted by a formylglycine-generating enzyme to produce a 2-formylglycine (FGly)-modified Ig polypeptide. An FGly-modified Ig polypeptide can be covalently and site-specifically bound to a moiety of interest to provide an Ig conjugate. The disclosure also encompasses methods of production of such aldehyde-tagged Ig polypeptides, FGly-modified Ig polypeptides, and Ig conjugates, as well as methods of use of same.

Aldehyde-tagged immunoglobulin polypeptides and methods of use thereof

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Emeryville, CA, United States of America

Robyn M Barfield