Perkinelmer Informatics, Inc.

Cambridgesoft Corporation

Sapphiros Laboratories LLC

Sapphiros Ai Bio LLC

Symyx Technologies, Inc.

Symyx Solutions, Inc.

Orig3n, Inc.

Revvity Signals Software, Inc.

Robin Young Smith

William Brian Ballard

Scott Gregory Flicker

Marcie A Glicksman

Andrew Smellie

Daniel Malcolm Oberlin

Sunil Anant Gupta

Sean Gerard Greenhow

David Albert Coleman

Biying Huang

Shadrack Cgar Frazier, Sr

Nikhat F Zaidi

Mike Robbat

Hans Keil

Nisarg Mehta

Julie E Nelson

Sonal Shashikant Kulkarni

Beau Guy Tremblay

Brandon William Arther Graham

Joshua Benjamin Wakefield

Jordan Haneil Shatsoff

Amy Annette Hahn

Benjamin James Davis

Michael Stapleton

Mike Stapleton

A meter value that reflects the amount of genetic material stored in a reserve is stored in a database for each reserve in a bank. Meter values allow a user to track the amount of genetic material in the reserves of a bank without needing to physically measure or disturb the reserves unnecessarily. As users withdraw and deposit genetic material from and into a reserve, the meter value is changed to reflect the change in the amount of genetic material in the reserve. In certain embodiments, the use of meter values enables accurate and instant accounting of a large number of reserves of genetic material for a large number of individuals. Users and/or individuals may be notified when a meter value falls below a threshold. Notifications may prompt a user to generate additional genetic material from biological sample or an individual to provide additional biological sample.

Systems and methods for automated monitoring and replenishment of genetic material reserves

The disclosed technology relates generally to devices, kits, and related methods for collecting biological samples for genetic testing. In various embodiments, a DNA collection device for collecting cells from an orifice of a human subject includes an elongate arm. The DNA collection device further includes a swab head disposed at a distal end of the elongate arm, wherein the swab head is sized to at least partially enter the orifice, and wherein the swab head comprises a plurality of bristles disposed on a surface of the swab head.

DNA collection device

Reserves of immortalized genetic material are stored in a bank for providing a resource (e.g., artificial gametes) for couples (e.g., same sex couples) to produce biologically-related children. The reserves provide the ability to derive sperm from induced pluripotent stem cells (iPSCs) of one partner and/or eggs from iPSCs of the other partner. For example, a biological sample is stored as iPSCs that can be used to generate an unlimited supply of genetic material (e.g., artificial gametes for conception) when needed by a user (e.g., a year or more after the sample is provided, e.g., 5 years or more after the sample is provided). Such a bank is helpful for an individual in a same sex (or infertile) couple who desires to have biological children at some point during his/her lifetime, but does not plan to have children in the immediate timeframe, for example.

Systems and methods of assisted reproduction and prevention of genetic defects in offspring using induced pluripotent stem cells

Described herein are various systems and methods for customizing cell culture media for optimized cell proliferation based on genetic traits of the cells. Factors of the cells, such as genetics, can determine the optimum cell culture conditions for growth and use of individual cells in vitro. In certain embodiments, genetics can determine sensitivity from a toxic perspective. In certain embodiments, genetics can determine what concentration(s) of growth factor(s) and nutrient(s) are required for optimum growth.

Systems and methods for customizing cell culture media for optimized cell proliferation based on genetic traits of cells

Described herein are various systems, methods, and apparatus for systematic creation of isolated homogeneous colonies of cells from vector-based lineages. The vector-based lineages may originate from multiple types of viral vector families (e.g., Paramyx-oviridae, Retroviridae, Parvoviridae) or non-natural engineered vectors or a plurality of vector combinations, for example. In certain embodiments, the isolated homogeneous colonies of cells are vector-free sub-colonies; in other embodiments, the isolated homogeneous colonies of cells are homogeneous vector sub-colonies. In other embodiments, vector mixed sub-colonies are created. The disclosed systems, methods, and apparatus are useful for inducible pluripotent stem cell (iPSC) production and work by selectively binding to one or more corresponding protein markers expressed on the surface of a cell that indicate that cellular reprogramming has occurred. Software is used to automate the purification and isolation of the iPSCs produced.

Systems, methods, and apparatus for induced pluripotent stem cell isolation and combinatorial production

Systems, methods, and apparatus are provided that allow a user to draw and edit a chemical structure using one or more gestures performed on an input interface. For example, the user may assign an atom label to a chemical structure representation by performing a press and tap gesture, change a chemical bond characteristic in the chemical structure representation by performing a tap gesture, and/or lengthen a molecular chain in the chemical structure representation by performing a drag gesture. The user may also rotate the chemical structure representation in the graphical display by performing one or more rotation gestures.

Systems, methods, and apparatus for drawing and editing chemical structures on a user interface via user gestures

In certain embodiments, the invention relates to systems, methods, and apparatus that allow a user to visually augment a graphical rendering of either a chemical structure representation or a biological sequence representation with multi-dimensional information. A user captures a video image using a computing device such as a hand-held smart phone, computerized eye glasses or tablet computer. The video image includes information regarding at least one of a chemical structure and a biological sequence. A processor identifies, within the video image, a graphical representation of at least one of a chemical structure and a biological structure. The processor augments the graphical representation with additional information and provides the video data for presentation upon a display controlled by the computing device. The computing device presents the video data in substantially real time in relation to the capture of the video data by the computing device.

Visually augmenting a graphical rendering of a chemical structure representation or biological sequence representation with multi-dimensional information

Disclosed are methods for diagnosing Parkinson's disease, or identifying a risk of developing Parkinson's disease, comprising measuring the amount of a biomolecule in a blood sample, liver sample, or hepatocyte. Also disclosed are methods for preventing or treating Parkinson's disease, comprising administering a therapeutically effective plurality of hepatocytes to a subject in need thereof.

Diagnosis and treatment of parkinson's disease based on identification and amelioration of liver dysfunction

Systems, methods, and apparatus are provided that allow a user to draw and edit a chemical structure using one or more gestures performed on an input interface, such as a touch pad or touch screen. For example, the user may assign an atom label to a chemical structure representation by performing a press and tap gesture, change a chemical bond characteristic in the chemical structure representation by performing a tap gesture, and/or lengthen a molecular chain in the chemical structure representation by performing a drag gesture. The user may also rotate the chemical structure representation in the graphical display by performing one or more rotation gestures.

Described herein are various embodiments of systems, methods, and apparatus that allow a user to share data, such as one or more files from within an application with one or more other (not necessarily co-located) computing devices using a gesture-based sharing function. In a particular example, systems, methods, and apparatus described herein may be used to share graphical representations of chemical structures within a chemical structure rendering application between two or more user devices. By offering a user a quick and visually intuitive option for sharing a file with other user(s) without exiting a current application, the systems, methods, and apparatus described herein provide efficient and engaging tools for sharing work product in real time between two or more users.

Systems and methods for gesture-based sharing of data between separate electronic devices

Systems, methods, and apparatus are provided that allow a user to draw and edit a chemical structure using one or more gestures performed on an input interface, such as a touch pad or touch screen. For example, the user may rotate the chemical structure representation in the graphical display by performing one or more rotation gestures.

Systems, methods, and apparatus for drawing chemical structures using touch and gestures

Described herein are systems, methods, and apparatus that allow a user to convert various styles of three dimensional graphic representations of molecular models to computer aided design format to enable printing of a physical model using three dimensional printing equipment such as rapid prototyping equipment, additive manufacturing equipment, and/or three dimensional printers.

Systems and methods for translating three dimensional graphic molecular models to computer aided design format

An information management system creates data structures based entirely on the content of source files, then compares these data structures to discover synergies and commonalities. In one embodiment, the system accepts a first collection of source files, and extracts text from each source file. The text is compared to tags in one or more dictionaries, which comprise hierarchical listing of tags. Tags matching the text are associated with each source file. The system then generates a virtual relational network in which each source file having matching tags is a node. Tags associated with two or more source files are links between the nodes. This virtual relational network may be compared with another virtual relational network to discover common nodes or links. Source files later added to a collection are massively linked by associating all tags from all source files with the newly added source file, and vice versa.

Information management system

Creating a graphical representation of at least one of a chemical structure and a biological structure using a touch screen interface may include identifying connection location(s) of an in-progress structure and connection location(s) of a separate structure element, determine, upon receipt of a gesture input moving the structure element towards the in-progress structure, that a distance between a first connection location of the in-progress structure and a first connection location of the structure element signals an intended connection of the structure element to the in-progress structure at or about the corresponding connection locations, analyze a resultant structure formed by connection of the in-progress structure and the structure element at or about the corresponding connection locations to determine a response, and provide a visible cue, an audible cue, and/or a haptic cue corresponding to the response.

Growing community of inventors

Boston, MA, United States of America

Robin Young Smith