University of Colorado

Endoshape, Inc.

Abbott Medical Optics Inc.

Robin Shandas

Malik Y Kahook

Naresh Mandava

Bryan Rech

Michael B Lyons

Jeffrey Paul Castleberry

Michael D Lowery

Devatha P Nair

Daniel Urbaniak

Julie Marie Trommeter

James Fogelberg

Michael Zimkowski

Christopher Bowman

Stephen A Johnson

Neil Brian Cramer

Daewon Park

Timothy Francis Scott

Brisa Pena-Castellanos

Steven H Lewis

Avery Nelson

Omid Jazaeri

Steven Lammers

James Bardill

Jim Fogelberg

Mike Lyons

Jeff Castleberry

Bill Aldrich

Provided herein is a class of reversible thermal gel polymers, formulations thereof, methods for using, and methods for making said reversible thermal gel polymers. Reversible thermal gel polymers and formulations are provided having versatile chemical, physical, mechanical and/or optical properties beneficial for a range of applications including medical treatment. In some embodiments, the architecture and composition of the polymer allows for tunable selection of one or more physical properties supporting a particular application.

Reverse thermal gels and their use as vascular embolic repair agents

Formulations of shape memory polymer (SMP) are integrated with several existing clinically available medical fabrics. The SMP portion of a SMP-integrated fabric can be fabricated in varying thicknesses with the minimum thickness determined by the thickness of the underlying fabric and up to almost any thickness. Integration of the SMP with the base fabrics does not alter the shape memory functionality of the SMP. The design tools for controlling activation rate for traditional SMP materials thus apply to SMP-integrated fabrics. SMP-integrated fabrics may also be steam sterilized without loss of shape memory functionality.

Medical fabric with integrated shape memory polymer

A shape memory polymer (SMP) intraocular lens may have a refractive index above 1.45, a Tg between 10&#xb0; C. and 60&#xb0; C., inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum. The intraocular lens is then rolled at a temperature above Tg of the SMP material. The intraocular device is radially compressed within a die to a diameter of less than or equal to 1.8 mm while maintaining the temperature above Tg. The compressed intraocular lens device may be inserted through an incision less than 2 mm wide in a cornea or sclera or other anatomical structure. The lens can be inserted into the capsular bag, the ciliary sulcus, or other cavity through the incision. The SMP can substantially achieve refractive index values of greater than or equal to 1.45.

Intraocular lenses

A shape memory polymer (SMP) intraocular lens may have a refractive index above 1.45, a Tg between 10&#xb0; C. and 60&#xb0; C., inclusive, de minimiz or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum. The intraocular lens is then rolled at a temperature above Tg of the SMP material. The intraocular device is radially compressed within a die to a diameter of less than or equal to 1.8 mm while maintaining the temperature above Tg. The compressed intraocular lens device may be inserted through an incision less than 2 mm wide in a cornea or sclera or other anatomical structure. The lens can be inserted into the capsular bag, the ciliary sulcus, or other cavity through the incision. The SMP can substantially achieve refractive index values of greater than or equal to 1.45.

Shape memory polymer intraocular lenses

A shape memory polymer (SMP) intraocular lens may have a refractive index above 1.45, a Tg between 10&#xb0; C. and 60&#xb0; C., inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum. The intraocular lens is then rolled at a temperature above Tg of the SMP material. The intraocular device is radially compressed within a die to a diameter of less than or equal to 1.8 mm while maintaining the temperature above Tg. The compressed intraocular lens device may be inserted through an incision less than 2 mm wide in a cornea or sclera or other anatomical structure. The lens can be inserted into the capsular bag, the ciliary sulcus, or other cavity through the incision. The SMP can substantially achieve refractive index values of greater than or equal to 1.45

Formulations of shape memory polymer (SMP) are integrated with several existing clinically available medical fabrics. The SMP portion of a SMP integrated fabric can be fabricated in varying thicknesses with the minimum thickness determined by the thickness of the underlying fabric and up to almost any thickness. Integration of the SMP with the base fabrics does not alter the shape memory functionality of the SMP. The design tools for controlling activation rate for traditional SMP materials thus apply to SMP integrated fabrics. SMP integrated fabrics may also be steam sterilized without loss of shape memory functionality.

Shape memory materials (SMM) are formed as coil-shaped vascular occlusion devices upon deployment. Shape memory polymer (SMP) materials are tailored through formulation for specific mechanical behavior of the coils. Concurrent coil diameter changes enhance the relative change in stiffness along the length of the coil. Interconnecting structures () are formed on ends of elongated members () in the pre-deployment shape for multiple coil insertion capability within an introducer. Channels () are formed in pre-deployment shape, elongate members () that allow access for injection of imaging contrast agent or concurrent placement of instruments. A single SMM occlusive device () transforms into multiple, smaller diameter coils () in the deployed state to generate a complex occlusive structure. A SMM occlusive device () has a collapsed fabric () component attached to and extending along a sidewall during storage and insertion, and then deploys as a coil () to form a single- or multiple-layer occlusive fabric surface within a center of the coil ().

Vascular occlusion devices

A prosthetic medical device is formed by the combination of a biological tissue a shape memory polymer structure. The biological tissue provides an in-situ physiological function of the device. The shape memory polymer provides a capability for minimizing the device profile during insertion and then deploying after placement into a memory shape that achieves suitable mechanical structure and stability within an anatomical lumen or cavity. This configuration may be applied to form various prosthetic devices including aortic, mitral, and tricuspid valves in the heart; venous valves; anti-reflux valves for the lower esophageal sphincter; and other biological valve structures. Alternatively, an entirely non-biologic implementation using only shape memory polymer-based structures may be used as a prosthetic valve device.

Shape memory polymer prosthetic medical device

An implantable ophthalmological device () in the form of a punctal plug or canalicular implant is configured for use at or near the nasolacrimal drainage system. In a deployed state, the device () may include an elongated body (), an anchor () operably connected to the elongated body (), a radially expanding occlusive feature disposed on an outer circumference of the elongated body (), and a flange (). The elongated body () may define a lumen () configured to receive a pharmacological treatment (). The device () is made of a shape memory material such as a shape memory polymer.

Reliably retained shape memory ophthalmological implants

A variety of biomedical devices are provided which include thiol-ene or thiol-yne shape memory polymers. The biomedical devices of the invention are capable of exhibiting shape memory behavior at physiological temperatures and may be used in surgical procedures. Methods of making the devices of the invention are also provided.

Growing community of inventors

Boulder, CO, United States of America

Robin Shandas