Enzo Therapeutics, Inc.

Enzo Life Sciences, Inc.

Robin S Quartin

James G Wetmur

Dean L Engelhardt

Christine L Brakel

Disclosed is a nuclease resistant nucleotide compound capable of hybridizing with a complementary RNA in a manner which inhibits the function thereof, which modified nucleotide compound includes at least one component selected from the group consisting of MNM, B(N)M and M(N)B wherein N is a phosphodiester-linked modified 2'-deoxynucleoside moiety; M is a moiety that confers endonuclease resistance on said component and that contains at least one modified or unmodified nucleic acid base; B is a moiety that confers exonuclease resistance to the terminus to which it is attached; and x is an integer of at least 2.

Modified nucleotide compounds

Procedures and compositions for forming and stabilizing non stable branch migrated oligo- and polydeoxynucleotides utilizing a displacer which is either single stranded or partially double stranded and hybridized to a linker strand. The displacer may contain one or more modified nucleotides.

Growing community of inventors

Bedminster, NJ, United States of America

Robin S Quartin