Mayo Foundation for Medical Education and Research

Roche Molecular Systems, Inc.

Robin Patel

Franklin R Cockerill, Iii

Lynne M Sloan

Sabine Lohmann

Ulrike Salat

Kristi L Frank

James Fowler Greenleaf

Arlen Dale Hanssen

Andrej Trampuz

This document provides methods and materials related to reducing biofilms. For example, enzymes (e.g., glycosyl hydrolases), nucleic acid molecules encoding enzymes, host cells containing nucleic acid encoding enzymes, and methods for using enzymes to reduce biofilms and infections associated with biofilms are provided.

Methods and materials for reducing biofilms

The invention provides methods to detectand/orin a biological sample. Primers and probes for the differential detection ofandare provided by the invention. Articles of manufacture containing such primers and probes for detectingand/orare further provided by the invention.

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Methods, kits, and systems for removing microbial biofilms from surfaces of objects (such as, e.g., explanted medical devices) are disclosed. The methods, kits, and systems rely on the use of acoustic energy in the presence of microbubbles to enhance biofilm removal while retaining viability of the microorganisms in the biofilm. The microbubbles may be provided in a variety of manners such as, e.g., vortexing a liquid, obtaining a suspension that includes pre-formed protein-stabilized microbubbles, etc.

Microbial biofilm removal methods and systems

Detection of bordetella

Growing community of inventors

Rochester, MN, United States of America

Robin Patel