American Home Products Corporation

American Home Products Corporation (del.)

Robin P Enever

Thomas W Leonard

Karol Kay Mikula

Maureen M Harrison

Ronald N Warner

Robert P Waranis

Kathleen L Brunelle

Richard P Weierstall

Gerard F Thone

Disclosed herein is an aqueous, injectable rapamycin solution comprising 0.1 to 10 percent of a concentrate solution of rapamycin in N,N-dimethylacetamide, at concentrations of rapamycin ranging from 0.25 mg/ml to 100 mg/ml, in combination with a diluent solution consisting of 0.1 to 10 weight percent of one or more polyoxyethylene sorbitan esters, 10 to 60 weight percent of either polyethylene glycol 200 or 300 or both and 30 to 90 volume percent water, wherein the concentration of rapamycin in he combined solution ranges from 0.05 mg/ml to 5.0 mg/ml. Also disclosed is an aqueous, injectable solution of rapamycin, said solution comprising rapamycin in 0.1 to 10 weight percent N,N-dimethylacetamide, 0.09 to 7.5 weight percent of one or more polyoxyethylene sorbitan esters, 9 to 60 weight percent of either polyethylene glycol 200 or 300 or both and 30 to 90 volume percent of water, wherein the concentration of rapamycin in the solution ranges from 0.05 mg/ml to 5.0 mg/ml. Preferred aqueous, injectable rapamycin solutions are those wherein one polyoxyethylene sorbitan ester is present and the polyethylene glycol present is polyethylene glycol 300.

Rapamycin formulation for IV injection

There are provided pharmaceutical dosage forms for oral administration comprising a gelatin capsule encapsulating an admixture of at least one solid hygroscopic medicinal substance, which would otherwise disturb the gastric tract balance, with an at least partially hydrogenated and/or solidified vegetable oil.

Formulations for hygroscopic pharmaceuticals

The invention provides a transdermal/transmucosal pharmaceutical delivery system having an improved drug reservoir comprising a thin layer of foamed material made from high molecular weight polyethylene, the foamed material having a void volume of at lesat 20% per unit of surface area and a narrow pore size variation per unit of surface area.

Transdermal drug delivery system

A therapeutic composition for trans-mucosal administration in the treatment of diabetes including insulin, as an adjuvant a water-soluble fusidic acid salt and as a co-adjuvant methylparaben and/or propylparaben.

Growing community of inventors

Rouses Point, NY, United States of America

Robin P Enever