Nitto-denko Corporation

Amylin Pharmaceuticals, Inc.

Astrazeneca Pharmaceuticals LP

Robin Lee

Priya Prakash Karmali

Victor Knopov

Richard P Witte

David Webb

Violetta Akopian

Priya Karmali

Scott H Coleman

Robert N Jennings

Hong Qi

Greg Oehrtman

Mary L Houchin

What is described is a method for preparing a liposome that efficiently encapsulates a negatively charged therapeutic polymer, e.g., siRNA. The process involves preparing a lipid mixture comprising a cationic lipid in a water miscible organic solvent, such as ethanol, at a concentration of 2.3 mg/ml, and adding this solution to the polymer dissolved in water to a final concentration of 35% ethanol in water. The final charge ratio of drug:lipid is 1:2.5. The resulting nanoparticles have a mean size of 50 to 150 nm.

Method of producing lipid nanoparticles for drug delivery

What is described is a process of forming lipid-nucleic acid nanoparticles simply and reproducibly under aseptic conditions comprising single use components.

Single use system for sterilely producing lipid-nucleic acid particles

The disclosure provides one-component, injectable, sustained release formulations which comprise microspheres containing active pharmaceutical ingredients (e.g., exenatide), wherein the microspheres are suspended in a non-aqueous carrier. The non-aqueous carrier can be an oil, a fractionated oil, triglycerides, diglycerides, monoglycerides, propylene glycol fatty acid diesters, and the like. The formulations offer distinct advantages of long shelf life for the stability and potency of the formulation and sustained release of active pharmaceutical ingredients to reduce the frequency of medication dosing and to increase patient compliance.

Sustained release formulations using non-aqueous carriers

Growing community of inventors

San Diego, CA, United States of America

Robin Lee