Glaxo Laboratories Limited

Robin Lawrence

Gordon H Phillipps

Christopher Earle Newall

Martin Christopher Cook

Niall Galbraith Weir

Leslie Stephenson

Michael Wright

Anne Christine Hunter

Steroid anaesthetics of the pregnane and 19-norpregnane series are described, the steroids having a 3.alpha.-hydroxy group, a 17.alpha.-hydrogen atom, a 20-oxo group and at the 21-position a cyano, azido or basic amino group.

Steroidal anaesthetics of the pregnane and 19-norpregnane series

Steroid anaesthetics of the pregnane and 19-norpregnane series are described, the compounds possessing a 3.alpha.-hydroxy group, a 17.alpha.-hydrogen atom, a 20-oxo group and at the 21-position the residue of a sulphur nucleophile or a sulphone or sulphoxide grouping.

Anaesthetic steroids of the pregnane and 19-norpregnane series having a

Steroids of the androstane and pregnane series possessing a 2.alpha.-hydrogen or halogen or an alkyl group; a 3.alpha.-hydroxy or acyloxy group, a 3.beta.-hydrogen or alkyl group; an 11.beta.-hydrogen or hydroxy group or an epoxy group linked also to the 9-position; an 11.alpha.-hydrogen or alkyl or allyl group; or an 11-oxo group; a 16 hydrogen or halogen or a methyl or dimethyl group; a 20-oxo or ethylenedioxy group; and a 20-methyl or alkoxy group. The compounds may be unsaturated at the 1(2), 8(9) or 9(11) positions. The compounds possess anaesthetic properties.

Anaesthetic steroids of the androstance and pregnane series

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Robin Lawrence