Ortho-mcneil Pharmaceutical Corp.

Janssen Pharmaceutica Nv

Janssen Pharmaceuticals, Inc.

Robin L Thurmond

Lars Karlsson

Jianmei Wei

Steven P Meduna

Hui Cai

Siquan Sun

James Patrick Edwards

Barbara A Pio

Kevin L Tays

Yin Gu

Cheryl A Grice

Haripada Khatuya

Ronald L Wolin

Brad M Savall

Darin J Gustin

Frank Chavez

Xiaohu Zhang

Andrew J Greenspan

Sherry Baker

Jorge A Quiroz

Paul J Dunford

Curt A Dvorak

J Guy Breitenbucher

Chandravadan R Shah

Nicholas I Carruthers

Wenying Chai

Timothy W Lovenberg

Kiev S Ly

Wei Xiao

Anne Fourie

Jill A Jablonowski

Clark A Sehon

Scott A Wadsworth

Annette K Kwok

Christopher R Butler

Jennifer D Kreisberg

Siguan Sun

Barbara Pio

Diamino-pyridine, pyrimidine and pyridazine compounds which may be used as Hreceptor modulators, and in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by Hreceptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.

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Diamino-pyridine, pyrimidine, and pyrazine modulators of the histamine H4 receptor

A method for treating an allergic condition, including an atopic allergic condition, using substituted pyrazoles.

Method for treating allergies using substituted pyrazoles

The present invention relates to a method for monitoring the effect of in vivo administration of Cathepsin S inhibitors by measuring accumulation of an intermediate degradation product of invariant chain (Ii), in particular the p10 Ii fragment, in blood of dosed subjects.

Method of monitoring the effect of Cathepsin S inhibitors

Heterocyclic compounds and methods of making them and using them.

Heterocyclic compounds

DNAs encoding monkey cathepsin S have been cloned and characterized. The recombinant protein is capable of forming biologically active protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.

Polynucleotide and polypeptide sequences of monkey cathepsin S

DNAs encoding canine Cathepsin S have been cloned and characterized. The recombinant protein is capable of forming biologically active protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.

Polynucleotide and polypeptide sequences of Canine Cathepsin S

A method for the treatment of an allergic condition, including an an atopic allergic conditions, using substituted pyrazoles.

The present invention describes peptide substrates of the metalloproteases, ADAM8, ADAM15 and MDC-L. The invention also describes methods using these peptides to discover pharmaceutical agents that modulate these proteases. The invention further describes CD23 processing activity for these enzymes that may have important therapeutic implications for the use of inhibitors of these enzymes in allergic diseases such as asthma.

Metalloprotease peptide substrates and methods

Use of cathepsin S inhibitors for the treatment of an allergic condition, in particular an atopic allergic condition, more specifically for the treatment of hay fever, asthma, atopic dermatitis or a food allergy.

Method for treating allergies

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San Diego, CA, United States of America

Robin L Thurmond