University of Illinois

Robin L Holland

Paul Joseph Hergenrother

Martin D Burke

Timothy M Fan

Fadi G Alnaji

Kelsie J Green

Leyi Wang

Diana Rose Ranoa

Christopher B Brooke

A saliva-based testing method that bypasses the need for RNA isolation/purification is described herein. In experiments with inactivated SARS-CoV-2 virus spiked into saliva, this method has a limit of detection of 500-1000 viral particles per mL, rivalling the standard NP swab method. Initial studies showed excellent performance with 100 clinical samples. This saliva-based process is operationally simple, utilizes readily available materials, and can be easily implemented by existing testing sites thus allowing for high-throughput, rapid, and repeat testing of large populations.

Saliva-based molecular testing for SARS-CoV-2

Growing community of inventors

Urbana, IL, United States of America

Robin L Holland