Imperial College Innovations Limited

Imperial Innovations Limited

Robin John Leatherbarrow

Edward William Tate

Andrew Simon Bell

Jennie Ann Hutton

James Antony Brannigan

Andrew Guy Livingston

Piers Robert James Gaffney

Sheyung Wang Jerry So

Renato Campos Vasconceles

Ludmila Georgieva Peeva

This invention provides compounds of formula (I) and salts thereof, which have activity as inhibitors of N-myristoyl transferase (NMT). The invention also relates to uses of such compounds as medicaments, in particular in the treatment of a disease or disorder in which inhibition of N-myristoyl transferase provides a therapeutic or prophylactic effect, including protozoan infections (such as malaria and leishmaniasis), viral infections (such as human rhinovirus and HIV), and hyperproliferative disorders (such as B-cell lymphoma). 

Compounds and their use as inhibitors of N-myristoyl transferase

According to the present invention, there is provided a process for the preparation of a first compound selected from peptides, oligonucleotides and peptide nucleic acids. The process comprises synthesizing the first compound and then separating the first compound formed in step (i) from a second compound, which is a reaction by-product of the synthesis of the first compound and/or an excess of a reagent used for the synthesis of a first compound by a process of diafiltration. The membrane used for the diafiltration process is stable in organic solvents and provides a rejection for the first compound which is greater than the rejection for the second compound.

Solvent resistant diafiltration of peptides, PNA or oligonucleotides

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Robin John Leatherbarrow