Becton Dickinson and Company Limited

Robin Hwang

Vincent J Sullivan

David B Montgomery

John A Mikszta

Zhaolin Wang

Brandi Ford

Juan Huang

Anjana Bhuta-Wills

A method of preparing a pharmaceutical composition is described, comprising 1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; 2) freezing said atomized formulation to form solid particles; and 3) drying said solid particles at about atmospheric pressure to produce a powder, wherein said drying is performed in the presence of vibration, internals, mechanical stirring, or a combination thereof. Another method is described, comprising 1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; 2) freezing said atomized formulation to form solid particles; and 3) drying said solid particles to produce a powder; wherein the atomized formulation comprises droplets having an average mean diameter of between about 35&#x3bc; and about 300&#x3bc;, and/or the powder comprises dried particles having an average mean diameter of between about 35&#x3bc; and about 300&#x3bc;. Compositions made by the above methods, and methods of using the compositions, are also described.

Pharmaceutical compositions in particulate form

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Cary, NC, United States of America

Robin Hwang