Promega Corporation

Robin Hurst

Keith V Wood

Thomas A Kirkland

Rachel Friedman Ohana

Dieter Klaubert

Poncho Meisenheimer

Paul Otto

Carolyn Woodroofe Hitko

Nidhi Nath

Harry Tetsuo Uyeda

Marjeta Urh

Ji Zhu

John William Shultz

Daniel J Simpson

Tonny Johnson

Sergiy Levin

Roderick G Flemming

Rebecca Godat

Sanchayita Kar

Provided herein are compositions and methods for photoaffinity labeling of molecular targets. In particular, probes that specifically interact with cellular targets based on their affinity and are then covalently linked to the cellular target via a photoreactive group (PRG) on the probe.

Photoaffinity probes

The present invention provides compositions and methods for capture and identification of the cellular targets of a bioactive agent. In particular, provided herein are bioactive agents tethered to capture ligand, cellular targets (optionally tagged with a reporter), capture proteins (optionally present as capture fusions), surfaces (e.g., displaying, capture ligands, capture proteins, or capture fusions), and methods of capturing and identifying the cellular targets of a bioactive agent therewith.

Compositions and methods for capture of cellular targets of bioactive agents

The present invention provides compositions and methods for capture and identification of the cellular targets of a bioactive agent. In particular, provided herein are bioactive agents tethered to capture ligand, cellular targets (optionally tagged with a reporter), capture proteins (optionally present as capture dimers), surfaces (e.g., displaying, capture ligands, capture proteins, or capture dimers), and methods of capturing and identifying the cellular targets of a bioactive agent therewith.

The present invention provides compositions and methods for the separation of metals or molecules such as polypeptides, nucleic acids, or endotoxins using a metal-modified solid support. The metals or molecules are isolated from a starting material using the modified solid supports of the invention. Also provided by the invention are kits that can be used in connection with the inventive methods.

Methods for separating molecules

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Madison, WI, United States of America

Robin Hurst