Vernalis Research Limited

Robin Gerald Shepherd

David Reginald Adams

Howard Langham Mansell

Ian Anthony Cliffe

Nathaniel Monck

Corinna Dagmar Bodkin

Allan Fletcher

James Edward Paul Davidson

Scott Murray Weiss

Lars Jacob Stray Knutsen

Jon Mark Bentley

By Joy Miriam Shepherd

Richard H P Porter

A compound of formula (1) wherein R is aryl; and R is hydrogen or alkyl; pharmaceutically acceptable addition compounds thereof; and their use in therapy, particularly for the treatment and prophylaxis of CNS disorders such as anxiety and epilepsy.

Azetidinecarboxamide derivatives for treating CNS disorders

Use of (&plus;)-(11R,2&prime;S)-&agr;-2-piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol or a pharmaceutically acceptable salt thereof substantially free of its (&minus;)-enantiomer in the manufacture of a medicament having reduced side-effect compared to the racemic (&plusmn;)-(R*,S*)-&agr;-2-piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol for treating or preventing malaria in a subject. A method of treating or preventing malaria with reduced side-effects comprising administration of (&plus;)-(11R,2&prime;S)-&agr;-2-piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol or a pharmaceutically acceptable salt thereof substantially free of its (&minus;)-enantiomer.

Use of (&plus;)mefloquine for the treatment of malaria

The present invention relates to the use of (&plusmn;)-R*,S*)-alpha-2-piperidnyl-2,8-bis(trifluoromethyl)-4-quinolinemthanol and in particular (&minus;)-(11S,2&prime;R)-alpha-2-piperidnyl-2,8-bis(trifluoromethyl)-4-quinolinemthanol in the treatment of disorders in which the reduction of purinergic neurotransmission could be beneficial. The invention relates in particular to adenosine receptors, and particularly adenosine A2a receptors and to the treatment of movement disorders such as Parkinson's disease.

(&minus;)-mefloquine to block puringergic receptors and to treat movement or neurodegenerative disorders

Growing community of inventors

late of Berkshire, undefined

Robin Gerald Shepherd