Baxter International Inc.

Baxter Healthcare Sa

Fenwal, Inc.

Robin Gail Pauley

Shmuel Sternberg

Daniel R Boggs

Robert A Clarke

James H Brauker

Donna L McLarty

Lecon Woo

Craig L Sandford

Richard I Brown

Ton That Hai

Birendra K Lal

Hsinjin E Yang

Rosa Yeh

Ronald S Hill

Dustin Christopher Cawthon

Kent Lane Lurvey

Sivaramakrishnan Krishnamoorthy

Mark Nordhaus

Vadim V Krongauz

Lee W Henderson

Michael Tung-Kiung Ling

Larry Black

William S Hoerle

Kenneth Glen Suh

Ashok K Khanna

Alexander Savitski

Nicklaus J Kirichkow

Atif M Yardimci

Mark Conrad Jones

Scott R Ariagno

Douglas W Reitz

Michael R Prisco

Siddharth Desai

David W Pennington

Derek J Hei

Laura A Martinson

Edwin Chim

Steven K Neuenfeldt

Lewis E Daniels, Jr

Gert Najdeni

Atul R Khare

Eddie K Chan

Brian R Micheli

Norma J Ofsthun

Siddarth B Desai

Mihir Sheth

Nicole Michaela Haupt Jabri

Arch Sites

James Patrick Condon

Mack David Elliott

Normal J Ofsthun

A dialysis bag is provided, including a first layer of film and a second layer of film each having a closed end and an opposite outlet end, the layers sealed together about corresponding peripheral edges to define a bag chamber. An outlet assembly is sealingly disposed at the corresponding outlet ends and has a tubular administrative outlet with an inlet and is in fluid communication with the bag chamber. A dimple is formed in at least one of the layers adjacent to the inlet for preventing occlusion as a fluid level decreases in the bag.

Dialysis bag with anti-occlusion feature

A priming indicator for a fluid infusion system includes a luer cap or other component of the infusion system having an indicator surface covered by a membrane. The membrane exhibits a first visual characteristic, such as being opaque, when dry and exhibits a second characteristic, such as becoming less opaque, when wet. Once the membrane becomes wet, indicia on the surface, which may be provided on a rod at least partially covered by the membrane, becomes visible, thereby indicating an intravenous tube to which the luer cap is secured has been primed or is nearly primed. The indicator may alternately be employed at an upstream end of an infusion set, such as at the port of a medical bag providing a supply of fluid, to indicate a low level of fluid in the medical bag.

Device to indicate priming of an infusion line

A medical device, such as a vascular access device, is disclosed for providing access to a medical fluid flow path for the introduction or withdrawal of medical fluids to and from the flow path. The access device includes an indicator for providing a visual indication when the access device has been exposed to an antiseptic agent.

Medical fluid access device with antiseptic indicator

Flow-through systems for processing biological fluid are disclosed. The flow-through systems include a removal device in the flow path for removing unwanted compounds and agents. The removal device includes a removal media contained within a housing made of two separate portions sealed together. The housing is maintained in a substantially vertical disposition, thereby ensuring substantially uniform and complete exposure of the fluid to the media.

Flow-through removal device and system using such device

Membranes and methods for making membranes are disclosed. The membranes include a polymeric matrix and a particulate material immobilized within the matrix. The membranes may find particular application in methods and apparatus for removing organic compounds from a biological fluid as part of a pathogen inactivation treatment.

Composite membrane with particulate matter substantially immobilized therein

Composite membranes and methods for making such membranes

Apparatus, membranes and methods for removing organic compounds from a

A permeable structure forms a chamber to hold living cells. The structure includes a first permeable region surrounding at least a portion of the chamber having a conformation that, when implanted in host tissue, substantially blocks penetration of host cells into the chamber while permitting solute transport. The structure also includes a second permeable region overlying the first permeable region having a conformation that, when implanted in host tissue, forms a permeable interface with host tissue that permits solute transport. A third permeable region is located between the first and second permeable regions. The third region comprises a solution of polymer material formed in place between the first and second permeable regions. The third permeable region bonds the first and second permeable regions together. The third permeable region also has a conformation that, when implanted in host tissue, permits solute transport between the first and second permeable regions. The third, formed-in-place region bonds the first and second permeable regions together, providing a robust, laminated structure that resists delamination during implantation caused by cellular infiltration into discontinuous spaces between the first and second regions. The third, formed-in-place region can also have a conformation providing an immunoisolation effect. Furthermore, the permeability of the third, formed-in-place membrane is sufficient high that it does not adversely effect the permeability value desired for the overall multiple layer membrane structure.

Multiple-layer, formed-in-place immunoisolation membrane structures for

Improved Implant assemblies and methodologies provide immuno-protection for implanted allografts, xenografts, and isografts. The assemblies and methodologies establish an improved chamber for holding the implanted cells. The chambers include first and second wall elements and an intermediate sealing element. The first and second wall elements overlie an open area in the sealing member to form a chamber for holding cells for implantation. A sealed region is created between the wall elements and the sealing element body to close the chamber. In one arrangement, the sealed region is created by means of a sonic weld made while the implanted cells are present in the chamber. In another arrangement, the sealed region is created by means of applying an external force to compress the peripheral edges of the wall elements and the sealing element together while the implanted cells are present in the chamber.

Closed porous chambers for implanting tissue in a host

The invention provides dual-skinned membranes useful as one way or rectifying membranes which reduce back filtration of solute molecules in dialysis and which improve nutrient supply and product recovery in membrane bioreactors. The membranes are dual-skinned polymeric materials preferably in the form of hollow fibers. The membranes have skins of polymer on the opposite sides with differing permeability to solutes and sieving coefficient characteristics. The skin on each side have pores that are invisible at 10,000 times magnification, the microporous structure between said skins contains pores capable of retaining solutes in a molecular weight range of about 5000 to 200000 in an increased concentration between the interior and the exterior skins. Improved dialysis devices are formed by using bundles of the hollow fiber membranes as a dialysis means having rectifying properties.

Rectifying dialyzer, bioreactor and membrane

Improved Implant assemblies and methodologies provide immuno-protection for implanted allografts, xenografts, and isografts. The assemblies and methodologies establish an improved boundary between the host and the implanted cells. The boundary structure is laminated, combining elements having different characteristics beneficial to the survival of the implanted cells. Filaments of adhesive material lay in between the elements. The filaments of adhesive material have been melted in place by the application of heat and solidified in place by cooling to secure the elements together into a composite laminated structure.

Laminated barriers for tissue implants

The invention employs dual-skinned membranes useful as one way or rectifying membranes which reduce back filtration of solute molecules in dialysis and which improve nutrient supply and product recovery in membrane bioreactors. The membranes are dual-skinned polymeric materials preferably in the form of hollow fibers. The membranes have sieving coefficient characteristics different for flow of liquids in one direction from that in the opposite direction. Improved dialysis devices are formed by using bundles of the hollow fiber membranes as a dialysis means having rectifying properties. Improved bioreactors are formed by using bundles of hollow fiber as a growth vessel having rectifying properties.

Process for removing unwanted materials from fluids and for producing

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Lake Villa, IL, United States of America

Robin Gail Pauley