Walter and Eliza Hall Institute of Medical Research

Saramane Pty., Ltd.

Robin Fredric Anders

Alan E Cowman

David J Kemp

Graham F Mitchell

Albert E Bianco

Ross Coppel

Pauline Elizabeth Crewther

Anthony Neil Hodder

Robert B Saint

David Pye

Mary Shu Mai Leet

Graham V Brown

An immunogenic polypeptide for use in inducing an immune response against Plasmodium infection comprises an amino acid sequence corresponding to a non-full length fragment of the apical membrane antigen 1 (AMA-1) of Plasmodium species which does not include a transmembrane domain thereof, and which is stabilised by folding thereof. Production of the immunogenic polypeptide by expression of a recombinant DNA molecule in a host cell, and methods and compositions using the immunogenic polypeptide are disclosed.

Malaria merozoite antigen subunit vaccine

DNA molecules comprising polynucleotide sequences substantially corresponding to all or a portion of the base sequence coding for an antigen of Plasmodium falciparum selected from the group consisting of the RESA antigen, the FIRA antigen, and other antigens of P. falciparum cross-reactive therewith. Such DNA molecules are capable of being expressed as polypeptide(s). Synthetic peptides or polypeptides displaying the antigenicity of all or a portion of the RESA or FIRA antigens of P. falciparum. Compositions for stimulating immune responses against P. falciparum antigens in a mammal, comprising at least one polypeptide displaying the antigenicity of the RESA or FIRA antigens of P. falciparum.

The RESA and FIRA antigens of plasmodium falciparum

Growing community of inventors

North Melbourne, Australia

Robin Fredric Anders