Medical Research Council

Otago Innovation Limited

University of Otago

Antipodean Pharmaceuticals, Inc.

United Kingdom Research and Innovation

Robin Andrew James Smith

Michael Patrick Murphy

Margaret Anne Brimble

Lesley Larsen

David Samuel Larsen

David Rennison

Russell James Hewitt

Morgan Jay-Smith

Joanne Clare Harrison

Gregory Giles

Ivan Andrew Sammut

Nathan John Stanley

Morgayn Iona Read

Laura Molly Woods

Jui Thiang Brian Kueh

Richard Charles Hartley

The present invention provides organic compounds which are capable of releasing carbon monoxide under physiological conditions or pH trigger, and to the use of such compounds for conditioning a cell, tissue or organ, for example, to protect against ischaemic injury during a transplant event.

Carbon monoxide releasing norbornenone compounds

The invention relates to compounds having Formula (1): A-L-B or pharmaceutically acceptable salts thereof, wherein: A is a dicarbonyl sequestering moiety comprising a substituted aryl group or a substituted heteroaryl group; L is an optional linker moiety; and B is a mitochondrial targeting moiety. The invention also relates to pharmaceutical compositions containing such compounds and salts, and to the use of such compounds and salts for treating diabetes, preferably hyperglycemic diabetes. A mass spectrometry probe and to a method of labelling a biological molecule 1 for mass spectrometry detection are also described.

Mitochondria-targeted dicarbonyl sequestering compounds

The invention relates to novel NO donors which are targeted to the mitochondria. The NO donor compounds of the invention allow NO to be selectively provided to the mitochondria.

Nitric oxide donors

The methods of preparing quinols and quinones typified by mitoquinol and mitoquinone where a compound typified by idebenone is reacted with PhPHX and PhP, where X is a halogen atom.

Synthesis of triphenylphosphonium quinols and quinones

Growing community of inventors

Dunedin, New Zealand

Robin Andrew James Smith