University of Virginia Patent Foundation

Other

Home Guardian LLC

Robin A Felder

Majd Alwan

Steven W Kell

J William Holman

B Sean Graves

John Savory

James C Boyd

Sarah G Wood

Beverly L Turner

James P Gunderson

Keith S Margrey

David C Mack

Siddharth Gautam Dalal

William P Holman

Chris Estey

Michael Cvetanovich

Pedro Jose

Randy Turner

Robert M Carey

John E Jones

Pedro A Jose

Keith S Margery

Scott M Williams

Antonia Martinez

Jonathan H Roberts

Steve Kell

A method and related system to, among other things, automatically infer answers to all of the ADL questions and the first four questions of the IADL in the home. The inference methods detect the relevant activities unobtrusively, continuously, accurately, objectively, quantifiably and without relying on the patient's own memory (which may be fading due to aging or an existing health condition, such as Traumatic Brain Injury (TBI)) or on a caregiver's subjective report. The methods rely on the judicious placement of a number of sensors in the subject's place of residence, including motion detection sensors in every room, the decomposition of each relevant activity into the sub-tasks involved, identification of additional sensors required to detect the relevant sub-tasks and spatial-temporal conditions between the signals of sensors to formulate the rules that will detect the occurrence of the specific activities of interest.

System and method for the inference of activities of daily living and instrumental activities of daily living automatically

It was determined whether SNPs in SLC4A5 are associated with salt sensitivity of blood pressure (BP). Subjects consumed an isocaloric constant diet with a randomized order of 7 days low Na(10 mmol/d) and 7 days high Na(300 mmol/d) intake. Salt sensitivity was defined as a &#x2267;7 mm Hg increase in mean arterial pressure (MAP). 35 polymorphisms in 17 candidate genes were assayed. Association analyses with salt sensitivity revealed three variants that associated with salt sensitivity, two in SLC4A5 (rs7571842, rs10177833; P&#x3c;0.001), and one in GRK4 (rs1801058; P=0.020). Paradoxical changes in blood pressure in response to changes in salt intake were also found associated with a SNP for DRD2 (rs6276). In conclusion, SLC4A5 variants are strongly associated with salt sensitivity of BP in Caucasian and a DRD2 SNP is a marker for paradoxical response to salt intake.

Compositions and methods for identifying and diagnosing salt sensitivity of blood pressure

Disclosed are methods for identifying individuals predisposed to essential hypertension and related conditions such as salt sensitivity by detecting the presence of polymorphic or mutant forms of the GRK4 gene, or its expression product. Also disclosed are methods for identifying polymorphic or mutant GRK4s in individuals known to be suffering from such conditions, as well as methods and compositions for conducting drug discovery and therapeutic intervention.

G protein-related kinase mutants in essential hypertension

The gait monitor system and method provides various basic gait parameters including step count, cadence, and step duration, in addition to its ability to distinguish between normal, limping and shuffling gait modes, as well as determine falls. Moreover, this gait monitor may be provided with additional sensors, e.g. beam break at the beginning and end of a corridor to estimate average walking velocity (with the distance between the beams known or determined); this enables the calculation of additional gait characteristics such as average step length and average stride length. These parameters can additionally be used to detect various gait anomalies and other diagnostic information.

Method and system for the derivation of human gait characteristics and detecting falls passively from floor vibrations

A plug capable of providing information relating to a physical or chemical property of a body fluid, or the presence or amount of a molecular component therein in a living organism is disclosed. Specifically, one embodiment plug is capable of being inserted into a portion of a human eyelid in order to provide information relating to tear fluid is disclosed. This embodiment plug includes a body having a passage which allows for the natural flow of tear fluid therethrough. In addition, a sensing mechanism is provided which is capable of measuring, for example, glucose levels in the body of a patient through the analysis of the tear fluid. Such plug may further be designed so as to double as a punctal plug useful in preventing dry eye. Methods of utilizing and implanting such plugs are also disclosed.

Microelectronic biosensor plug

A plug capable of providing information relating to a physical or chemical property of a body fluid, or the presence or amount of a molecular component therein in a living organism is disclosed. Specifically, one embodiment plug is capable of being inserted into a portion of a human eyelid in order to provide information relating to tear fluid is disclosed. This embodiment plug includes a body having a passage which allows for the natural flow of tear fluid therethrough. In addition, a sensing mechanism is provided which is capable of measuring, for example, glucose levels in the body of a patient through the analysis of the tear fluid. Such plug may further be designed so as to double as a punctual plug useful in preventing dry eye. Methods of utilizing and implanting such plugs are also disclosed.

A system and method for detecting, monitoring and analyzing physiological characteristics. Signals from a subject are acquired from a suite of sensors, such as temperature, carbon dioxide, humidity, light, movement, electromagnetic and vibration sensors, in a passive, non-invasive manner. The signals are processed and physiological characteristics are isolated for analysis. The system and method are to analyze sleep patterns, as well as to prevent bed sores or detect conditions such as illness, restless leg syndrome, periodic leg movement, sleep walking, or sleep apnea. However, numerous other applications of the invention are also disclosed.

System and process for non-invasive collection and analysis of physiological signals

System and method that can monitor pulse rate and passively produce a blood pressure measurement and automatically log the data for the user. Additionally, coupling to the Internet or Information Systems expands the options for the early detection of diseases, based on sudden detected changes and trend analyses, and the successful treatment of these patients while reducing the high costs associated with invasive procedures and in-hospital care.

System and method for passive monitoring of blood pressure and pulse rate

A system and method for detecting, monitoring and analyzing physiological characteristics. Signals from a subject are acquired from a suite of sensors, such as temperature, carbon dioxide, humidity, light, movement, electromagnetic and vibration sensors, in a passive, non-invasive manner. The signals are processed, and physiological characteristics are isolated for analysis. The system and method are to analyze sleep patterns, as well as to prevent bed sores or detect conditions such as illness, restless leg syndrome, periodic leg movement, sleep walking, or sleep apnea. However, numerous other applications of the invention are also disclosed.

A pick up and delivery system for use with mobile robots which have a body with a horizontal upper surface and at least one vertical side. The robot has at least one shelf, each of which contains a stop bar containing a retaining device. The system further uses multiple stations, each of which contain at least one pallet retaining surface to contain at least two pallets. The pallet retaining surfaces are provided with a holding device at the pick up area and a holding device at the delivery area. Pallets are used to retain the items being transferred with each of the pallets having a securing device that interacts with the holding device and retaining device. The strength of the holding device at the pick up area is less than the holding device at the delivery area, with the robot's retaining device having a strength between the strength of the holding devices. The mobile robot picks up a pallet from a first station, and delivers the pallet to a second station.

Robotic pick up and delivery system

An automated cold storage apparatus, and related method thereof, provides a sample process management system that is a revolutionary approach to the storage and retrieval regarding critical samples. The system&#x2014;a significant technological breakthrough in laboratory automation&#x2014;is the first ultra low temperature robotic system capable of being validated. Samples in containers are stored and retrieved robotically through an airlock climate-control chamber that is automatically dehumidified by a dry gas purge, such as a carbon dioxide or nitrogen purge or the like. This purge rapidly reduces ambient humidity to a desirable relative humidity (RH), e.g., less than about 15% RH, virtually eliminating the accumulation of frost. Microplates are systematically identified using barcode technology, for example. Once through the climate-controlled chamber, the containers (i.e., samples) are robotically transferred to the rotary mechanism. This mechanism transports the containers to a derived nest location upon the storage means, such as a carousel or to one of the stationary addresses.

Automated storage and retrieval apparatus for freezers and related method thereof

An automated cold storage apparatus, and related method thereof, provides a sample process management system that is a revolutionary approach to the storage and retrieval regarding critical samples. The system&mdash;a significant technological breakthrough in laboratory automation&mdash;is the first ultra low temperature robotic system capable of being validated. Samples in containers are stored and retrieved robotically through an airlock climate-control chamber that is automatically dehumidified by a dry gas purge, such as a carbon dioxide or nitrogen purge or the like. This purge rapidly reduces ambient humidity to a desirable relative humidity (RH), e.g., less than about 15% RH, virtually eliminating the accumulation of frost. Microplates are systematically identified using barcode technology, for example. Once through the climate-controlled chamber, the containers (i.e., samples) are robotically transferred to the rotary mechanism. This mechanism transports the containers to a derived nest location upon the storage means, such as a carousel or to one of the stationary addresses.

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Charlottesville, VA, United States of America

Robin A Felder