U.S. Philips Corporation

Robertus W J Hollering

Maarten Barmentlo

A method and a device for optically ascertaining the mutual binding of a first and a second reactant are described. Use is made of the fact that a dipolar layer (,) having a non-linear optical behavior is formed upon a reaction between the two reactants. The formation of such a layer is ascertained by illuminating the substance with radiation (,) having one or two frequencies, and by detecting whether radiation (,) from the substance contains a component at a frequency which is twice the frequency, or a mixed term of the frequency of the radiation incident on the substance.

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Eindhoven, Netherlands

Robertus W J Hollering