Zambon S.p.a.

Roberto Pagliarin

Dario Chiarino

Giancarlo Jommi

Replacement with fluorine of the primary hydroxy group of 1-phenyl-2-amino-1,3-propanediol compounds wherein the secondary hydroxy group and the amino group have been suitably protected. The reaction is carried out with an inorganic fluoride in a polyglycol. New oxazoline compounds particularly useful in said process.

Process for preparing 1-phenyl-2-amino-3-fluoro-1-propanols

Replacement with fluorine of the primary hydroxy group of 1-phenyl-2-amino-1,3-propanediol compounds wherein the secundary hydroxy group and the amino group have been suitably protected. The reaction is carried out with an inorganic fluoride in a polyglycol. New oxazoline compounds particularly useful in said-process.

Process for fluorinating 1-phenyl-2-amino-1,3-propanediol compounds and

Intermediates having the formula ##STR1## wherein R is --NO.sub.2, CH.sub.3 S--, CH.sub.3 SO--, or CH.sub.3 SO.sub.2 --, X.sub.1 is hydrogen, alkyl, haloalkyl, (substituted) phenyl or phenylalkyl and Y is F or --OSO.sub.2 R.sub.6 wherein R.sub.6 is methyl, trifluoromethyl, (substituted) phenyl naphthyl or pyridyl are disclosed.

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San Giorgio Su Legnano, Italy

Roberto Pagliarin