Novartis Ag

Chiron Corporation

Glaxosmithkline Biologicals Sa

Gsk Vaccines S.r.l.

Novartis Vaccines and Diagnostics Srl

Roberto Olivieri

Rino Rappuoli

Paolo Costantino

Francesco Berti

Francesco Norelli

Massimo Bugnoli

Fabio Sabbatini

Giulia Bazzocchi

Natale Figura

Silvia Fontani

Concetta Cicala

Antonella Giglioli

Lucia Tagliaferri

Maria Kontakou

Ilio Marsili

Concetta Maria Cicala

In place of a step of centrifugation during preparation of outer membrane vesicles (OMVs) from bacteria, the invention utilizes ultrafiltration. This allows much larger amounts of OMV-containing supernatant to be processed in a much shorter time. Thus the invention provides a process for preparing bacterial OMVs, comprising a step of ultrafiltration. The ultrafiltration step is performed on an aqueous suspension of OMVs after they have been prepared from bacteria and the OMVs remain in suspension after the filtration step. The invention is particularly useful for preparing OMVs from

Ultrafiltration for preparing outer membrane vesicles

The present invention relates to a medium containing non-animal derived proteinaceous material for cultivating patheogenic bacteria to produce an immunogenic factor and processes employing such medium.

Culture medium with yeast or soy bean extract as amino acid source and no protein complexes of animal origin

This invention is in the field of bacterial cultures and specifically relates to the optimization of culture conditions to improve the production of bacterial capsular polysaccharides fromstrains in fed batch culture and to novel purification methods suitable for production scale purification of bacterial capsular polysaccharides fromstrains resulting in higher levels of purity than previously obtained for production scale.

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Fermentation processes for cultivating streptococci and purification processes for obtaining CPS therefrom

Method for the culture of microorganisms of the genera Helicobacter, Campylobacter and Arcobacter, wherein culture media are employed, which comprise, in place of blood or its derivative, cyclodextrins, methylcellulose or mixtures thereof.

Method for the culture of microorganisms of the genera helicobacter,

Method for the culture of microorganisms of the genera Helicobacter, Campylobacter and Arcobacter, wherein culture media are employed, which comprise, in place of blood or its derivative, cyclodextrins.

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Siena, Italy

Roberto Olivieri