Ecole Polytechnique Federale De Lausanne

Bruker Biospin Ag

Ecole Polytechnique Féderale De Lausanne (Epfl)

Roberto Melzi

Geoffrey Bodenhausen

Frank Engelke

Sami Jannin

Antonio Giuseppe Gianotti

Joost Lohman

Aurélien Bornet

A method for producing hyperpolarized sample material for use in magnetic resonance investigations involves preparing a target material containing high &#x3b3; nuclei with a short T, a polarizing agent with a broad EPR line, and low &#x3b3; nuclei with a long T. The polarizing agent in the target material is irradiated with microwave radiation, wherein the target material is at a cryogenic temperature and exposed to a static magnetic field B&#x2267;4.0 T, thus polarizing the high &#x3b3; nuclei by DNP, and the polarization is transferred from the high &#x3b3; nuclei to the low &#x3b3; nuclei by Cross Polarization. A dissolved sample material is prepared containing the hyperpolarized low &#x3b3; nuclei from the target material. Nuclei with a long longitudinal relaxation time Tcan thereby be quickly hyperpolarized to a high polarization level.

MRI compatible method and device for rapid DNP on a solid state hyperpolarized sample material

Growing community of inventors

Pavia, Italy

Roberto Melzi