The United States of America, As Represented by the Secretary, Department of Health and Human Services

Aziende Chimiche Riunite Angelini Francesco A.c.r.a.f. S.p.a.

Roberto Di Santo

Roberta Costi

Guido Furlotti

Yves Pommier

Nicola Cazzolla

Angelo Guglielmotti

Maria Alessandra Alisi

Lorenzo Polenzani

Christophe Marchand

Marino Artico

Compound of formula (I) in which R1, R2 and R3 are defined in the following description, and the pharmaceutically acceptable acid-addition or base-addition salts thereof. The invention also relates to a process and an intermediate for preparing it, and to a pharmaceutical composition comprising it. The invention also relates to the use of a novel 2H-pyrrolo[3,4-c]quinoline compound for preparing a pharmaceutical composition that is active in the treatment of disturbances of the serotoninergic system. 

Compound with serotoninergic activity, process for preparing it and pharmaceutical composition comprising it

Novel quinoline inhibitors of retroviral integrase, particularly HIV-1 integrase. The quinoline inhibitors are oxoquinolines that can be used for preventing or treating AIDS or HIV infection in a subject.

Quinolin-4-ones as inhibitors of retroviral integrase for the treatment of HIV, AIDS and AIDS related complex (ARC)

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Rome, Italy

Roberto Di Santo