Universidad Miguel Hernández De Elche

Roberto De La Torre

Antonio Vicente Ferrer Montiel

Armando Genazzani

Juana Gallar Martinez

Carlos Belmonte Martinez

Asia Fernandez Carvajal

Gian Cesare Tron

Valentina Mercalli

The invention relates to compounds having formula (I) wherein A is selected from the group consisting of: a) optionally substituted (C-C) alkyl; b) optionally substituted (C-C) cycloalkyl; c) optionally substituted (C-C) aryl; d) optionally substituted (C-C) heteroaryl; e) C(O)&#x2014;(C-C) aryl, in which group (C-C) aryl is optionally substituted; f) C(O)&#x2014;(C-C) heteroaryl, in which group (C-C) heteroaryl is optionally substituted; g) CH(OH)&#x2014;(C-C) aryl, in which group (C-C) aryl is optionally substituted; and h) CH(OH)&#x2014;(C-C) heteroaryl, in which group (C-C) heteroaryl is optionally substituted. The invention also relates to methods for the production of said compounds, to pharmaceutical and veterinary compositions comprising said compounds and to the therapeutic uses thereof, such as for the prevention and/or treatment of dry eye syndrome, vaginal dryness and/or burning mouth syndrome.

TRPM8 receptor agonist compounds and uses thereof

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Alicante, Spain

Roberto De La Torre