Dompe S.p.a.

Domp&eacute; S.p.a.

Roberto Curti

Marcello Allegretti

Maria Candida Cesta

Luca Nicolini

Luigi Pellegrini

Gabriella Melillo

(&#xb1;) 3-(4-Phenyl-1-piperazinyl)-1,2-propanediol cyclic acetals, a process for the optical resolution thereof and their use as intermediates for the preparation of (&#x2212;) 3-(4-phenyl-1-piperazinyl)-1,2-propanediol (levodropropizine) and salts thereof are described herein.

Process for the preparation of (&#xb1;) 1-3-dioxolanes and the optical resolution thereof

(S)-3-(4-Phenyl-1-piperazinyl)-1,2-propanediol cyclic acetals useful as antitussive agents and as intermediates for the preparation of levodropropizine and the salts thereof, as well as a process for the preparation of said acetals, are disclosed.

1,3-dioxolanes with antitussive activity

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L'Aquila, Italy

Roberto Curti