Montedison S.p.a.

Dr. Lo. Zambeletti S.p.a.

Istituto Guido Donegani

Presidenza Del Consiglio Dei Ministri

Smithkline Beecham Farmaceutici

Dr. L. Zambeletti Spa

Agrimont S.r.l.

Dr. Lo. Zambelletti Spa

Lo Zambeletti S.p.a.

Roberto Colle

Franco Gozzo

Luigi Mirenna

Giovanni Camaggi

Carlo Garavaglia

Vittorio Vecchietti

Giuseppina Ratti

Giuseppe Giardina

Giulio Dondio

Ciro Preziuso

Antonio Giordani

Derek H Barton

Silvano Ronzoni

Francesco Corda

Giorgio Siddi

Angela Zagni

Walter Visentin

Antony G Barrett

Geoffrey D Clarke

Antonio Pizzi

##STR1## Compounds of formula (I) in which, R is linear or branched alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, aryl, aralkyl or furan-2-yl alkyl; R.sub.1 and R.sub.2, which may be the same or different, are each hydrogen, hydroxy, alkoxy, or halogen; R.sub.3 is hydrogen, hydroxy or alkoxy; 'Het' is optionally substituted single or fused heteroxyclic ring, containing from 5 to 10 ring atoms and comprising up to four heteratoms in the or each ring, selected from oxygen, nitrogen and sulphur; R.sub.4 and R.sub.5, which may be the same or different, are each hydrogen alkyl, halogen, nitro; CF, cyano, alkoxy carbonyl, NH, alkylcarbonylamino, hydroxy, alkoxy, or benzyl, are selective delta receptor agonists and are useful in the treatment of pain.

Hydroisoquinoline derivatives

##STR1## Azacyclic derivatives of formula (I), in which R.sub.1 and R.sub.2 are each linear or branched alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, cycloalkenyl or alkynyl; R.sub.3 and R.sub.4 are identical, and each is a hydrogen or alkyl; and R.sub.5 is hydrogen or alkyl, and their use in medicine are disclosed.

1-(2H-1-oxo-3,4-dihydronaphtyl-6-yl)-acetyl-piperidines as kappa agonists

N-acyl-substituted azacyclic compounds, processes for their preparaion,

A compound, or a solvate or salt thereof, of formula (I): ##STR1## in which: RCO is an acyl group in which the group R contains a substituted or unsubstituted carbocyclic aromatic or heterocyclic aromatic ring and R.sub.1 and R.sub.2 are independently hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.3-6 cycloalkyl or C.sub.4-12 cycloalkylalkyl groups or together form a C.sub.2-8 branched or linear polymethylene or C.sub.2-6 alkenylene group optionally substituted with a hetero-atom;

Substituted isoquinoline compounds, pharmaceutical composition and

A compound, or a solvate or salt thereof, of formula (I): ##STR1## in which: RCO is an acyl group in which the group R contains a substituted or unsubstituted carbocyclic aromatic or heterocyclic aromatic ring;

Heterocyclic piperidinyl compounds having analgesic effect

Compounds of formula (Ia), or pharmaceutically acceptable salts or solvates thereof, ##STR1## in which A, together with the nitrogen atom, represents --(CH.sub.2)p--, where p is an integer from 3 to 6, or an optionally substituted tetrahydroisoquinoline ring system;

Method for the treatment of a hyponatremic disease

Disclosed are compounds having the formula: ##STR1## wherein: m=0, 1;

Fungicidal azolyl-derivatives

A compound, or a solvate or salt thereof, of formula (I): ##STR1## in which R represents a group of formula (II) ##STR2## in which R.sub.x is the remainder of a heterocyclic group, or an optionally substituted phenyl group;

Tetrahydroisoquinoline and tetrahydrothieno derivatives

Disclosed are compounds, having the general formula: ##STR1## wherein: m=0, 1, 2; n=0, 1 with the condition that when m=0, also n=0;

Azolyl-derivatives endowed with antifungal activity

There are described compounds having general formula: ##STR1## wherein: R.sup.1 is selected from the group comprising F, Cl, Br, CF.sub.3, a phenyl, a C.sub.1 -C.sub.2 alkoxy, a C.sub.1 -C.sub.2 haloalkoxy, an alkylthio, a haloalkylthio radical, in which the halogen is F, Cl, Br;

Fungicide azolyl-derivatives

Compounds having the formula: ##STR1## wherein: m=1 or 2;

Azolyl-derivatives having fungicidal activity

Fungicidal compounds having the formula: ##STR1## wherein: R.sup.1 is selected from the group consisting of F, Cl, Br, CF.sub.3, a phenyl, a C.sub.1 -C.sub.2 alkoxy, a C.sub.1 -C.sub.2 haloalkoxy, an alkylthio, and a haloalkylthio radical, in which the halogen is F, Cl, or Br;

There are disclosed compounds having the formula (I) and (II): ##STR1## wherein: R' and R', equal to or different from each other, are a C.sub.1 -C.sub.7 alkyl, a C.sub.3 -C.sub.7 cycloalkyl, a heterocycloalkyl, alkoxyalkyl, dialkoxyalkyl, haloalkyl;

Triazolyl-keto-derivatives having fungicide activity

There are disclosed compounds having general formula (I): ##STR1## wherein: X is H, a phenyl, phenylalkyl, phenylcarbonyl, phenyloxy group, optionally substituted with a halogen; Y is N or CH; R.sup.1 is H or a phenyl group; R.sup.2 and R.sup.3, equal or different, are H, an alkyl, alkoxy group or together they are an atom of ketonic oxygen; R.sup.4 and R.sup.5, equal or different, are H or an alkyl group; R.sup.6 and R.sup.7, equal or different, are H, an alkyl group or one of them forms with R.sup.2 or R.sup.3 an alkylidenic or etheric bridge; or they form a dioxyalkylidenic or alkylidenic ring; m=0, 1; n=0, 1, 2, 3. The compounds are endowed with fungicide and systemic properties.

Growing community of inventors

Milan, Italy

Roberto Colle