Politecnico Di Milano

Nextmaterials S.r.l

Roberto Chiesa

Alberto Cigada

Matteo Santin

Gabriele Candiani

Luigi De Nardo

Enrico Sandrini

Gianni Rondelli

Cinzia Della Valle

Lia Rimondini

Elena Maria Varoni

Lina Altomare

A substrate of a metal selected from the group consisting of titanium, tantalum, titanium alloys and tantalum alloys, modified by anodic spark deposition (ASD) on the surface thereof of a microporous and nanoroughened layer of the oxide of the same metal, said layer being enriched with Ca, P, Si, Na, and at least one metal selected from Ag and Ga. This surface modified metal substrate show excellent osteointegrating properties associated with antibacterial activity. A further advantage resides in that its preparation process does no longer require alkaline etching to promote cellular adhesion.

Metal substrate modified with silicon based biomimetic treatment having antibacterial property for the osteointegration thereof

Dental implant with biomimetic osteointegrative interface has a substrate of biocompatible material with a first layer thereon, having a first concentration of oxide of the biocompatible material, enriched with a second concentration of phosphorus and with a third concentration of calcium. The ratio between the concentration of calcium and the concentration of phosphorus is greater than two and the biomimetic osteointegrative interface further comprising a second layer having a first surface in contact with the first layer, and a second surface, the second layer having a fourth concentration of oxide enriched with a fifth concentration of calcium and a sixth concentration of phosphorus, the fourth concentration being less than the fifth and sixth concentrations and the ratio between the fifth concentration of calcium and the sixth concentration of phosphorus being no less than three.

Osteointegrative interface

A method for the biomimetic treatment of an osteointegrative interface on a substrate of biocompatible metal of titanium, tantalum, or their alloys, includes performing a first anodic spark deposition (ASD) treatment of the osteointegrative interface in a calcium glycerophosphate solution, performing a second ASD anodic deposition treatment of the osteointegrative interface in a calcium hydroxide solution and performing an immersion of the osteointegrative interface in a potassium or sodium hydroxide solution.

Treatment of an osteointegrative interface

An interface including a substrate of biocompatible material such as titanium, tantalum or their alloys having, on the surface of the substrate, a first layer having a first concentration of oxide of the biocompatible material, enriched with a second concentration of phosphorus and with a third concentration of calcium, the ratio between the concentration of calcium and the concentration of phosphorus being greater than two. The interface also includes a second layer having a first surface in contact with the first layer and a second surface. The second layer has a fourth concentration of oxide enriched with a fifth concentration of calcium and a sixth concentration of phosphorus. The fourth concentration is less than the fifth and sixth concentrations and the ratio between the fifth concentration of calcium and the sixth concentration of phosphorus is no less than three.

Osteointegrative interface for implantable prostheses and a method for the treatment of the osteointegrative interface

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Vedano Olona, Italy

Roberto Chiesa