Massachusetts Institute of Technology

Beth Israel Deaconess Medical Center, Inc.

University of Pennsylvania

The Children's Hospital of Philadelphia

Roberto Accorsi

Richard C Lanza

John V Frangioni

John D Idoine

Francesca Gasparini

Scott Dean Metzler

Robert M Lewitt

This invention is directed to a collimator and collimation techniques. Specifically, the invention is directed to a collimator and method for collimation wherein the collimator combines the resolution and sensitivity properties of pinhole Single Photon Emission Computed Tomography (SPECT) imaging with the 2D complete-sampling properties of fan-beam collimators.

Slit-slat collimation

The invention relates to imaging systems that include a coded aperture detection system and an optical detection system. The coded aperture detection system is configured to detect radiation emitted by a radionuclide present within an object and to provide a first detector signal from the detected radiation. The optical detection system is configured to detect optical radiation from the object and to provide a second detector signal from the detected optical radiation. The system also includes a processor configured to prepare first image data from the first detector signal, second image data from the second detector signal, and registered data indicative of a spatial relationship in at least one dimension between the first and second image data. The invention also includes methods of using the new systems, e.g., for sentinel lymph node mapping and tissue resection.

Systems and methods for multimodal imaging using a volumetric representation of an object

Systems and methods for multi-modal imaging having a spatial relationship in three dimensions between first and second image data

Coded aperture imaging

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St. Davids, PA, United States of America

Roberto Accorsi