Diadexus, Inc.

Roberto A Macina

Yongming Sun

Herve Recipon

Chenghua Liu

Susana Salceda

Fei Yang

Leah R Turner

Sei-Yu Chen

Shu-Hui Liu

Robert Cafferkey

Jason Pluta

Alejandra Piderit

Yongmng Sun

Huei-Mei Chen

Rajeswari Pillai

John D Burczak

The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic ovarian cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating ovarian cancer and non-cancerous disease states in ovarian, identifying ovarian tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered ovarian tissue for treatment and research.

Compositions, splice variants and methods relating to ovarian specific genes and proteins

The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic ovarian cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating ovarian cancer and noncancerous disease states in ovarian, identifying ovarian tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered ovarian tissue for treatment and research.

Compositions and methods relating to ovarian specific genes and proteins

The present invention provides new methods for detecting, diagnosing, monitoring, staging, prognosticating, imaging and treating cancer.

Method of diagnosing, monitoring, staging, imaging and treating cancer

The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic breast cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating breast cancer and non-cancerous disease states in breast tissue, identifying breast tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast tissue for treatment and research.

Compositions and methods relating to breast specific genes and proteins

The present invention provides a new method for detecting, diagnosing, monitoring, staging, and prognosticating lung cancer.

Method of diagnosing, monitoring, and staging lung cancer

The present invention provides a new method for detecting, diagnosing, monitoring, staging, prognosticating, imaging and treating gynecologic cancers including uterine, breast, endometrial and ovarian cancer.

Method of diagnosing, monitoring, staging, imaging and treating gynecologic cancers

The present invention provides a new method for detecting, diagnosing, monitoring, staging, prognosticating, imaging and treating gastointestinal cancers including small intestine, colon and stomach cancer.

Method of diagnosing, monitoring, staging, imaging and treating gastrointestinal cancers

The present invention provides new methods and agents for detecting, diagnosing, monitoring, staging, prognosticating, imaging and treating gastrointestinal cancer.

Method of diagnosing, monitoring, staging, imaging and treating gastrointestinal cancer

The present invention provides a new method for detecting, diagnosing, monitoring, staging, and prognosticating colon cancer.

Method of diagnosing, monitoring, and staging colon cancer

Method of diagnosing monitoring, staging, imaging and treating cancer

The present invention provides new methods for detecting, diagnosing, monitoring, staging, prognosticating, imaging and treating lung cancer.

Method and antibody for imaging lung cancer

The present invention provides new methods for detecting, diagnosing, monitoring, staging, prognosticating, imaging and treating colon cancer.

Method of diagnosing, monitoring, staging, imaging and treating colon cancer

The invention relates to CSG polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.

The present invention provides a new method for diagnosing cancers, particulary endometrial and uterine cancer.

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San Jose, CA, United States of America

Roberto A Macina