Memorial Sloan Kettering Cancer Center

Ludwig Institute for Cancer Research Limited

Agenus Inc.

Roberta Zappasodi

Gerd J Ritter

Taha Merghoub

Marc A Van Dijk

Jedd David Wolchok

Nicholas Stuart Wilson

David Schaer

David Adam Savitsky

Cornelia Anne Mundt

Dennis John Underwood

Volker Seibert

Takemasa Tsuji

Olivier Léger

Ana M Gonzalez

Rikke Baek Holmgaard

Rikke Bæk Holmgaard

Mark Arthur Findeis

Jean-Marie Cuillerot

Olga Shebanova

Igor Proscurshim

Marc Van Dijk

Volker Siebert

Olivier Leger

Nicolas S Wilson

Provided are antibodies that specifically bind to CTLA-4 and/or PD-1 and antagonize CTLA-4 and/or PD-1 function. Also provided are pharmaceutical compositions and kits comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies either alone or in combination.

Antibodies and methods of use thereof

The present disclosure provides antibodies that specifically bind to human glucocorticoid-induced TNFR family related receptor (GITR) and compositions comprising such antibodies. In a specific aspect, the antibodies specifically bind to human GITR and modulate GITR activity, e.g., enhance, activate or induce GITR activity, utilizing such antibodies. The present disclosure also provides methods for treating disorders, such as cancer and infectious diseases, by administering an antibody that specifically binds to human GITR and modulates GITR activity e.g., enhances, activates or induces GITR activity.

Anti-GITR antibodies and methods of use thereof

The instant disclosure provides antibodies that specifically bind to human PD-1 and antagonize PD-1 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Anti-PD-1 antibodies and methods of use thereof

Growing community of inventors

New York, NY, United States of America

Roberta Zappasodi