Fidia Farmaceutici S.p.a.

Antibioticos S.p.a.

Roberta Pizzocaro

Angelo Bedeschi

Marco Alpegiani

Giovanni Pozzi

Paolo Ghetti

Aldo Banfi

Gialunca Belogi

Claudio Fuganti

Stefania Galimi

Emilio Vecchio

Gaetano Balsamo

Ettore Negri

Gianluca Belogi

Alessia Rossi

A process for the preparation of Rotigotine (I) and of pharmaceutically acceptable salts thereof, which comprises the reductive amination of an amine of formula 6 with the 2-thienylacetic acid-sodium boron hydride complex and which makes use of hydrobromide 5 as an intermediate (II). The process is advantageous from the industrial point of view in that it allows to obtain Rotigotine with high enantiomeric purity starting from optically active 5,6,7,8-tetrahydro-6-(S)-N-propylamino-1-methoxynaphthalene (2), avoiding the use of dangerous reactives, the need for difficult chromatographic separation or the formation of by-products. Furthermore, two novel crystalline forms are disclosed. 

Process for the preparation of rotigotine

Adefovir Dipivoxil monohydrate crystalline is disclosed.

Adefovir dipivoxil crystalline monohydrate form

Disclosed is a crystalline form of irinotecan hydrochloride (I) and processes for the preparation thereof from crude irinotecan hydrochloride or another polymorphic form of irinotecan. Said crystalline form is particularly suitable for industrial use, because it is easily filtered and possesses characteristics of high stability and purity. 

Crystalline irinotecan hydrochloride and methods for its preparation

A process for the preparation of valgancyclovir which comprises: in an aprotic solvent, in the presence of a condensing agent, with a compound of formula 8, wherein R, and Rmay be, each independently, hydrogen, an halogen atom or an hydroxyl group; the double bond may either be in the E or Z configuration or a mixture thereof to yield a compound of formula 9 

Process for the preparation and purification of valgancyclovir hydrochloride

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Rodano, Italy

Roberta Pizzocaro