Bracco Imaging S.p.a.

Roberta Mazzon

Roberta Fretta

Pier Lucio Anelli

Fulvio Uggeri

Luciano Lattuada

Attilio Citterio

Massimo Visigalli

Gabriella Leonardi

Aurelia Ferrigato

Evelin Vignale

Gabriele Meli

The present invention relates to a process for the preparation of a solid form of the gadobenate dimeglumine compound that comprises obtaining a solution of the said compound in a suitable solvent A wherein the amount by weight of the water optionally present in the solution is at most equal to or lower than the amount by weight of the gadobenate dimeglumine comprised in the solution and adding the obtained solution to an organic solvent B, acting as an appropriate antisolvent and favoring the formation of a solid form of the gadobenate dimeglumine that can be collected by filtration.

Preparation of a solid form of gadobenate dimeglumine

The present invention relates to a process for the preparation of iodinated anilines; in particular, it relates to a process including the direct iodination, with suitably activated iodine, of 3,5-disubstituted anilines to the corresponding 3,5-disubstituted-2,4,6-triiodoanilines, which are useful intermediates for the synthesis of x-ray contrast media, and to the preparation of the contrast media themselves. 

Process for the iodination of aromatic compounds

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Volpiano, Italy

Roberta Mazzon