Second Genome, Inc.

Roberta L Hannibal

Todd Zachary DeSantis

Cheryl-Emiliane T Chow

Nicole R Narayan

Jayamary Divya Ravichandar

Compositions, systems and methods for generating and using internal standard spike-in mixes including a combination of template spikes. Compositions, systems and methods described herein are directed to using the internal standard spike-in mixes to evaluate a set of workflow pipelines to perform differential abundance analyses on a sample containing variations of a target nucleic acid sequence of interest. Compositions, systems and methods described herein are directed to using the internal spike-in mixes to validate results obtained from differential abundance analyses performed on a sample containing variations of a target nucleic acid sequence of interest, where the variations may be of highly variable levels of relative abundance.

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San Francisco, CA, United States of America

Roberta L Hannibal