Bracco Imaging S.p.a.

Sicor Inc.

Roberta Fretta

Luciano Lattuada

Pier Lucio Anelli

Fernanda Di Giorgio

Carlo Felice Viscardi

Pietro Delogu

Alfonso Nardelli

Stefano Sguassero

Roberta Mazzon

Fulvio Uggeri

Laura Galimberti

Andrea Banin

Aurelia Ferrigato

Gabriele Meli

Marco Villa

Alessandro Pontiroli

Attilio Citterio

Marino Brocchetta

Roberta Napolitano

Massimo Visigalli

Nicola Diulgheroff

Pierfrancesco Morosini

Sonia Gazzetto

Gabriella Leonardi

Silvia Ceragioli

Alessandro Barge

Armando Mortillaro

Giancarlo Cravotto

Evelin Vignale

Francesca Baricco

Roberto Arosio

Pier Francesco Morosini

The invention relates to a process for preparing Gadoteridol of formula (I). In particular, the process comprises the use of propylene oxide in the alkylation step of the compound of formula (II), wherein propylene oxide is directly reacted with the compound of formula (II) without being isolated, and wherein propylene oxide is obtained on demand by decomposition of propylene carbonate in the presence of an alkaline or alkaline earth metal halide as catalyst.

Manufacturing process for preparing gadoteridol

The invention relates to a process for the recovery and recycling of the iodine from aqueous solutions comprising iodine-comprising aromatic compounds in which the iodine contained in said aromatic compounds is directly converted into molecular iodine at a pH lower than 1, in the absence of a catalyst.

Process for the recovery of iodine from aqueous solutions

The present invention relates to the calcium complex of (4RS)(4-carboxy-5,8,11-tris(carboxymethyl)-1-phenyl oxa-5,8,11-triazatridecan-13-oato(5-))pentahydrogen (BOPTA) in the form of a salt, to the process for its preparation and to a formulation comprising said salt.

Calcium BOPTA complex

The present invention relates to a process for the preparation of a solid form of the gadobenate dimeglumine compound that comprises obtaining a solution of the said compound in a suitable solvent A wherein the amount by weight of the water optionally present in the solution is at most equal to or lower than the amount by weight of the gadobenate dimeglumine comprised in the solution and adding the obtained solution to an organic solvent B, acting as an appropriate antisolvent and favoring the formation of a solid form of the gadobenate dimeglumine that can be collected by filtration.

Preparation of a solid form of gadobenate dimeglumine

The present invention generally relates to a process using a mechanochemical approach exploiting the mechanical milling of reactants for the manufacturing of acetyl Iopamidol and, more generally, of key intermediates of radiographic contrast agents, and of the contrast agents themselves.

Mechanochemical synthesis of radiographic agents intermediates

The present invention relates to a method for the acetylation of an aqueous solution of lactic acid to (S)-2-acetyloxypropionic acid. The process comprises in particular removing water from the solution of lactic acid and reacting lactic acid with acetic anhydride in the presence of acetic acid.

Method for the preparation of (S)-2-acetyloxypropionic acid and derivatives thereof

The present invention discloses a process for the preparation of gadobenate dimeglumine complex in a solid form. In particular, said solid form is conveniently obtained by spray-drying a corresponding liquid suspension at a given temperature and concentration. The present invention is particularly advantageous for the industrial scale as the solid form may be obtained by employing water as a solvent, which is a non-toxic solvent, easy to handle and basically not requiring troublesome health or safety precautions.

Process for the preparation of gadobenate dimeglumine complex in a solid form

The present invention relates to a process for the preparation of iodinated anilines; in particular, it relates to a process including the direct iodination, with suitably activated iodine, of 3,5-disubstituted anilines to the corresponding 3,5-disubstituted-2,4,6-triiodoanilines, which are useful intermediates for the synthesis of x-ray contrast media, and to the preparation of the contrast media themselves. 

Process for the iodination of aromatic compounds

The present invention relates to a process for the preparation of given carboxamido compounds, in particular of 2,4,6-triiodoisophthalic acid derivatives, as useful intermediates for the preparation of X-ray contrast media among which is iopamidol. The said process comprises reacting suitable N-sulfinyl intermediate compounds with a commercially available &#x3b1;-hydroxyacid or a salt thereof.

Process for the preparation of triiodinated carboxylic aromatic derivatives

A process for preparing Anastrozole is provided. In the process the steps of a. combining 3,5-bis(2-cyanoisopropyl)toluene, a solvent selected from the group consisting of acetonitrile, dichloromethane and chlorobenzene, a brominating reagent selected from a group consisting of N-bromosuccinimide and 1,3-dibromo-5,5-dimethylhydantoin, and 2,2'-azobis(2-methylpropionitrile);

Process for the preparation of anticancer drugs

Growing community of inventors

Collegno, Italy

Roberta Fretta