Italfarmaco Spa

Roberta Cereda

Francesca Benedini

Alberto Sala

Aldo Banfi

Piero Del Soldato

Silvio Levi

Sala Alberto

Piero Soldato

##STR1## Compounds of formula (I) wherein X, Y, R.sub.1 and R.sub.2 have the meanings specified in the specification, are endowed with cardiovascular activity.

Benzoic acid substituted derivatives having cardiovascular activity

Isoindole compounds of the formula (I) ##STR1## wherein R.sub.1 represents hydrogen; C.sub.1 -C.sub.6 alkyl; benzyl optionally substituted with halogen, hydroxy, C.sub.1 -C.sub.6 alkoxy, methylenedioxy; C.sub.2 -C.sub.8 aliphatic acyl; benzoyl optionally substituted with halogen, hydroxy, C.sub.1 -C.sub.6 alkoxy, C.sub.2 -C.sub.6 alkanoyl, C.sub.2 -C.sub.6 alkanoyloxy, C.sub.1 -C.sub.4 alkyl, trifluoromethyl, methylenedioxy;

Isoindoles having cardiovascular activity

Benzoxazinone and benzothiazinone derivatives of formula ##STR1## wherein R represents hydrogen, (C.sub.2-6)alkyl, (C.sub.5-7)cycloalkyl, phenyl, substituted phenyl; R.sub.1 and R.sub.2 independently represents hydrogen, halogen, (C.sub.1-4)alkyl, (C.sub.1-4)alkoxy or trifluoromethyl; X is oxygen or sulfur; Y is (C.sub.2-6)alkylene or (C.sub.5-7)cycloalkylene; and salts therewith of pharmaceutically acceptable acids. The compounds possess cardiovascular activity with high specificity for the coronary district.

Benzoxazinone and benzothiazinone derivatives endowed with

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Milan, Italy

Roberta Cereda