Incyte Genomics, Inc.

Nerviano Medical Sciences S.r.l.

Roberta Bosotti

Antonella Isacchi

Olga Bandman

Jens Berthelsen

David M Hodgson

Simon Plyte

Emanuela Scacheri

Paola Magnaghi

Angela Molteni

The present invention provides a human polypeptide homolog of DBF4/ASK1 (for 'Activator of S phase kinase') and polynucleotides which identify and encode DRF1 (for 'DBF4 Related Factor 1'). In addition, the invention provides expression vectors, host cells and methods for its production. The invention also provides methods for the identification of DRF1 or DRF1-containing complex agonists/antagonists, useful for the treatment of human diseases and conditions.

Human homologue of the DBF4/ASK1 protein, nucleic acids, and methods related to the same

The invention provides a nucleic acid molecule which encodes the human NIM1 kinase. It also provides for the use of the nucleic acid molecule, fragments, variants and complements thereof and of the protein, portions thereof and antibodies thereto for characterization, diagnosis, evaluation, treatment, or prevention of disorders associated with expression. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic organism or model system.

Human NIM1 kinase

Growing community of inventors

Nerviano, Italy

Roberta Bosotti