Italfarmaco Spa

Roberta Artico

Paolo Mascagni

Marco Adami

Tiziano Oldoni

Giuseppe Colombo

Maria Valmen Monzani

Silvia Puccianti

Daniele Barbareschi

Jaime Moscoso

Physically and chemically stable oral liquid formulations of Givinostat (Diethyl-[6-(4-hydroxycarbamoyl-phenylcarbamoyloxymethyl)-naphthalen-2-yl-methyl]-ammonium chloride) are disclosed, together with methods for the preparation thereof. Such oral formulations are in the form of aqueous suspensions and contain Givinostat and/or pharmaceutically acceptable salts and/or derivatives thereof, at least a wetting agent and/or at least a density-imparting agent. Such formulations are suitable for oral administration for systemic therapeutic action.

Physically and chemically stable oral suspensions of givinostat

Physically and chemically stable aqueous oral suspensions of riluzole and manufacturing methods thereof. The suspensions contain riluzole in particle form and at least a wetting agent, preferably a surfactant. Riluzole is present in amounts from about 0.1% to about 20% w/v and has an average particle size lower than 200 &#x3bc;m. The suspensions are devoid of the known local (mouth) anaesthetic effects of riluzole.

Riluzole aqueous suspensions

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Milan, Italy

Roberta Artico