Jagotec Ag

Centre National De La Recherche Scientifique

Immupharma France Sa

Ureka Sarl

Immupharma Sa

Elro Pharma

Robert Zimmer

Ubaldo Conte

Pascal Grenier

Guy Vergnault

Gilles Guichard

Jean-Paul Briand

Lauretta Maggi

Sylviane Muller

Juliette Fremaux

José Courty

Jean Paul Briand

Chantal Devin

Annie Lang

Ara Hovanessian

Haixing Zhang

It is described a new method for the preparation of pharmaceutical tablets carrying poorly soluble in water principle; this method allows to obtain tablets with fast and/or slow release of the active principle. The peculiar feature is the fact that the poorly soluble in water active principle (es: nifedipine) is treated with a surfactant, during the granulation phase or whatever during the preparation process; the obtained product, subjected to a compression, produces pharmaceutical tablets which show high bioavailability of the carried active principle. This procedure can be used to prepare polymeric matrixes (with modified release), formed by tablets with one or more layers. The procedure of manufacture and the characteristics of the new finished tablet are described.

Controlled release pharmaceutical tablets containing an active principle of low water solubility

Described herein is a particular type of pharmaceutical tablet, for oral use, which is formed by one or more layers, and is specifically designed for controlled release of active principles that present problems of bio-availability linked to absorption in the gastro-intestinal tract, and in particular active principles that present an erratic and unpredictable absorption linked to the presence or absence of food at the level of the stomach and/or of the first portion of the small intestine, the said pharmaceutical form being characterized in that it is completely coated with one or more films of a biocompatible and biodegradable polymeric material.

Pharmaceutical tablet, completely coated, for controlled release of

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Mulhouse, France

Robert Zimmer