Genzyme Corporation

Integrated Genetics, Inc.

Robert Wydro

William R Dackowski

Suzanne Groet

Ake Lundwall

Edward Cohen

Jonathan Ostman

Disclosed are a transformed mammalian cell that produces biologically active Protein S, and a vector for effecting the transformation of the cell. produces biologically active human Protein S, and the vector used to effect the transgenesis of the cell. The vector disclosed includes DNA encoding mature human Protein S, under the transcriptional control of a eukaryotic metallothionein gene, and also includes the transforming region of the bovine papilloma virus genome, and a fragment of SV40 DNA.

Vector containing DNA encoding mature human protein S

Method of binding nucleic acid to a nucleic acid-binding support comprising depositing the nucleic acid onto the support and then contacting the nucleic acid and the support with a liquid binding solution which is compatible with the support and which contains an organic solvent which is capable of binding the DNA to the support, for a period of time sufficient to effect the binding.

Binding nucleic acid to a support

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Framingham, MA, United States of America

Robert Wydro