University of Glasgow

Pharmathene, Inc.

Robert Wilson

Jonathan Cooper

Julien Reboud

Allan Watkinson

David Woodhouse

A device is disclosed for the preparation of nebulised droplets, for inhalation. The device has: a surface acoustic wave (SAW) transmission surface; a SAW transducer adapted to generate and propagate SAWs along the SAW transmission surface; and an array of cavities opening at the SAW transmission surface for containing a liquid. In operation, SAWs propagating along the SAW transmission surface interact with the liquid in the cavities to produce nebulised droplets of the liquid. Operation of the device results in a nebulised plume of droplets of average diameter in the range 1-5 &#x3bc;m.

Nebulisation of liquids

Surface acoustic wave device for the nebulisation of therapeutic liquids

An anthrax vaccine with alhydrogel as the adjuvant is presented in a composition formulated by mixing rPA with colloidal alhydrogel (alum) adjuvant to produce the final product, comprising 200 &#x3bc;g/ml rPA bound to 0.26% alhydrogel in phosphate buffered saline (PBS), said formulation containing an optimal concentration of phosphate. Methods of using the vaccines to treat or prevent infections are also presented.

Anthrax vaccine formulation and uses thereof

Growing community of inventors

Glasgow, United Kingdom

Robert Wilson