Kyphon Sarl

Merck Patent Gesellschaft MIT Beschrankter Haftung

Sanatis Gmbh

Merck Patent Gmbh

Warsaw Orthopedic, Inc.

Kyphon Inc.

Merck Patent Gesellschaft

Robert Wenz

Jörg Meyer

Wolfgang Ritter

Avram Allan Edidin

Berthold Nies

Paul M Sand

Jeffrey D Schwardt

Samuel S Lee

Thomas A Slater

Joerg Meyer

Peter Pokinskyj

Ralf Krotz

Ferdinand Driessens

Ann M Heike

Ferdinand C M Driessens

Samuel Lee

Jorg Meyer

Stephanie Louie

The present invention relates to a composition comprising: a) a first component comprising a poly(methyl met 5 hacrylate) (PMMA), a contrast agent, a radical donor and calcium based particles; and b) a second component comprising methyl methacrylate (MMA), a radical scavenger, and a polymerization accelerator; wherein the composition has an average setting time of about 13 minutes.

Calcium particle-embedded, snap-to-dough, high-viscosity bone cement

Disclosed herein is a composition suitable for use in spinal surgery. The composition generally includes a reaction product or settable mixture of first and second components, the first component including a spray-dried inorganic filler, a radical donor, and a pre-polymerized vinyl polymer, and the second component including a radical scavenger, a diluent, a polymerization accelerator, and a reactive monomer. Furthermore, disclosed herein is a method of making the composition, which generally includes mixing the first and second components under conditions suitable to form a curable reaction product.

Bone cement composition and method of making the same

Calcium-strontium-hydroxyphosphate (strontium-apatite-) cement preparations are described, comprising a powder mixture, which contains molar quantities of the components calcium (Ca), strontium (Sr) and phosphate (P) in the mixture in the ranges 1.00&#x3c;Ca/P&#x2266;1.50 and 0&#x3c;Sr/P&#x3c;1.5, together with an alkali salt or an ammonium salt of phosphoric acid, and with water and/or an aqueous solution. The powder mixture particularly contains, as the Ca-component, Ca(PO)(TCP), and as the Sr-component SrHPOand/or Sr(PO)and optionally additional SrCO. As the aqueous mixing solution for the formation of the strontium-apatite cement, an aqueous solution of an alkali salt or an ammonium salt of the phosphoric acid is suitable.

Strontium-apatite cement preparation cements formed therefrom, and use thereof

The present invention relates to novel bone substitute compositions and methods of use. It further encompasses the use of these novel bone substitute compositions for bone augmentation and the treatment of disease conditions. The invention also contemplates a kit including bone substitute compositions and a percutaneous delivery device.

Bone substitute compositions and method of use

A self-foaming bone cement is described herein. In one variation, the bone cements include a self setting calcium phosphate cement formulation which when cured, forms macroscopic pores of varying sizes and densities with sufficient surface area to provide substantial regions for bone turnover.

Self-foaming cement for void filling and/or delivery systems

The disclosure is directed to a composition includes a first component and a second component. The first component includes a poly(methyl methacrylate) (PMMA), a contrast agent, and a radical donor. The second component includes methyl methacrylate (MMA), a radical scavenger, and a polymerization accelerator. The composition has an average setting time of about 13 minutes. The disclosure is further directed to a kit and a method of making the above-mentioned composition.

Bone cement composition and method

Strontium-apatite cement preparations, cements formed therefrom, and uses thereof

The invention relates to methods, compositions, kits and systems for determining one or more cement material properties. In one variation, a color change agent is introduced into bone cement to allow a physician to determine when a cement has the desired viscosity for insertion into a patient. In another variation, the composition comprises one or more curable bioactive agents and one or more color change agents. The curable bioactive agent(s) may be one or more bone cement(s). These Bone cements contain a color change agent that allows a physician to tell when the cement has reached the property viscosity for insertion of the bone cement into a patient at the bone site.

Bone cement compositions comprising an indicator agent and related methods thereof

Strontium-apatite-cement-preparations, cements formed therefrom, and uses thereof

The apparatus for production of mixtures from two components has a container for each and devices to combine the components in the mixing space and for extrusion of the mixture. The powdered component () is situated in the lower part of the inner space (), which is sealed by a bottom (). This carries a nozzle () with closure membrane (). The inner space () is closed on the top by the lower wall () and the sliding seal (). The liquid component () is situated in the inner space () of the inner hollow cylinder (). This is closed on the top by the upper wall (). The lower and upper wall () and () each have an opening with sealing lips () and () that are closed by parts of the mixing rod (). A torus (), a section with smaller diameter (), a mixing disk (), as well as a mandrel (), are present on the lower part of the mixing rod ().

Apparatus and methods for mixing two components

The invention describes biodegradable calcium phosphate cements, in particular mixtures of calcium phosphate-containing powders of different stoichiometric composition, the precipitated hydroxylapatite present being a cation-deficient hydroxylapatite of the formula 1, with the result that the mixtures have improved properties with regard to compressive strength.

Biocements having improved compressive strength

The invention relates to an injectable curable bone cement paste based on bioresorbable hydroxyapatite-like compounds comprising calcium phosphate, which contains a cationic antibiotic in the form of a salt, preferably of its sulfate, the curable biodegradable bone cement releasing the antibiotic in biologically active concentrations with depot-like action over a long period of time. The bone cements according to the invention are suitable for the treatment of infectious inflammations of the bone and of the bone marrow, in particular as a result of bone defects and bone fractures.

Growing community of inventors

Wollstadt, Germany

Robert Wenz