University of California

More Health, Inc.

Robert Warren

Bruce J Tromberg

Robert Tienhan Chang

Thomas O'Sullivan

Bo Hu

Philippe Depeille

Shaista Malik

Goutham Ganesan

Chaoyi Du

Pietro Galassetti

Hope Lewis

Xuannan Wang

Jeremy Gao

Jeroen Roose

A quantitative, non-invasive optical spectroscopy technique for measuring dynamic changes in adipose tissue structure and metabolism in vivo. The technique requires multiple wavelengths of light in the near-infrared (650-1000 nm). Using these wavelengths of light, adipose tissue is illuminated and light that returns to a photodetector is analyzed. From the return signals, the absorption and reduced scattering coefficients (&#x3bc;and &#x3bc;') at each wavelength are calculated. The obtained &#x3bc;and &#x3bc;&#x2032; values allow for quantification of biomarkers and indices which allow for measurement of fat composition and metabolism. The concentration of oxy- and deoxy-hemoglobin, the fractional water and lipid content, and information about the size distribution of light scatterers in the adipose tissue are also determined. A detailed and quantitative understanding of fat composition and metabolism is thereby provided which describes the effectiveness of interventions to improve the health of a patient.

Predicting weight loss and fat metabolism using optical signal changes in fat

Provided herein are methods for selecting a drug therapy for a patient with cancer, such as colorectal cancer, pancreatic cancer, lung cancer or breast cancer. The method includes determining or measuring the level of RasGRP1 polynucleotide or polypeptide in a sample from the patient. Also provided herein are methods for determining the likelihood of a good prognosis for a patient with cancer. Additionally, provided herein are methods for predicting the likelihood of a negative clinical response to an anti-EGFR therapy in a subject with cancer.

Prognostic and diagnostic methods for colorectal cancer

Systems and methods of the present invention enable low latency viewing of medical images over a network and therefore can fulfill the functionality that is required for an international DICOM viewing platform. The system includes a server and a client that communicates with each other in the background and reduces image viewing latency in multiple aspects. When a user contacts the server using a web browser, the server sends the client to the user's computer over the network. The client runs from the browser and will send signals to the server to allow the server to load data into memory from storage one or more steps before the user requests the data, reducing latency on the server. The client will download and cache image data one or more steps before the user begins to view the images, and as a result latency from network transmission is also reduced.

Low latency web-based DICOM viewer system

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San Francisco, CA, United States of America

Robert Warren