Boston Scientific Scimed, Inc.

Minnesota Mining and Manufacturing Company

Cardiac Pacemakers, Inc.

Boston Scientific Neuromodulation Corporation

3m Innovative Properties Company

Boston Scientific Corporation

Robert Warner

Liliana Atanasoska

Scott Schewe

Jan Weber

Michele L Zoromski

Andrew John Ouderkirk

Douglas Scott Dunn

J Thomas Ippoliti

Michael Arney

Rajesh Radhakrishnan

Thomas J Holman

John A Nielsen

Mourad Rahi

John B Blix

Tracee E Eidenschink

Mark Lynn Jenson

James Lee Shippy, Iii

Scott Raymond Smith

Patrick A Haverkost

Jason P Hill

Richard F Theissen

James A Pontuti

James Q Feng

Robert Charles Fitzer

Ronald J Tabar

Michael J Root

David John Sogard

Benjamin Y Arcand

Victor Leo Schoenle

Matt Heidner

Eric Michael Petersen

Kasyap Venkata Seethamraju

Jeannette C Polkinghorne

Mark Theodore Wolters

Madeline P Shinbach

Steven M Spencer

Paul Vincent Grosso

Chandru Chandrasekaran

Joseph H Incremona

Steve M Spencer

John T Simpson

Ben Arcand

Ljiljana Liliana Atanasoska

David B Redmond

L Liliana Atanasoska

J Lee Shippy, Iii

Jesse Christian Thiesen-Toupal

Amy Grovender

Barry Cool

Arthur A Aamodt

Joshua Speros

Dan Everson

Michael S Arney

Scott R Schewe

Liliana L Atanasoska

The disclosure pertains to hemostatic compositions comprising a plurality of nonwoven fibers disposed in a rapidly soluble solid matrix and methods of making and using the same. The compositions may also comprise one or more therapeutic agents.

Hemostatic compositions and methods of making and using same

This disclosure pertains to controllably bioabsorbable devices, particularly anchors for vascular closure plugs and to methods of use thereof.

Vascular closure device with biodegradable anchor

An implantable device includes at least one electrode comprising a conductive base and polyoxometalate anions disposed on or within the conductive base; and at least one conductor attached to the at least one electrode for conducting electrical energy to the at least one electrode.

Implantable electrodes containing polyoxometalate anions and methods of manufacture and use

In embodiments, a stent includes a copolymer having a modulus of about 10 MPa or less and exhibiting hydrolytic degradation substantially by surface erosion. For example, the copolymer can include elastic segments formed of trimethyl carbonate polymer or copolymer, and rigid segments formed of a lactide, glycolide, &#x3b5;-caprolactone polymer or copolymer.

Block copolymer-coated endoprosthesis

Implantable or insertable medical devices that have one or more composite regions. These composite regions include polymer and sol-gel derived ceramic. The polymer and sol-gel ceramic may form bi-continuous phases or separate polymeric and sol-gel derived ceramic phases.

Polymeric/ceramic composite materials for use in medical devices

In accordance with an aspect of the invention, implantable or insertable medical devices are provided that comprise (a) a substrate and (b) a porous layer comprising close packed spherical pores disposed over the substrate. The porous layer may also comprise a therapeutic agent. In another aspect, the present invention provides methods of forming implantable or insertable medical devices. These methods comprise forming a predecessor structure that comprises (i) a substrate over which is disposed (ii) an assembly of microspheres. This assembly of microspheres is then used as a template for the formation of a porous layer, which may be subsequently loaded with a therapeutic agent.

Drug eluting medical devices having porous layers

Bioerodible endoprostheses and methods of making the endoprostheses are disclosed. In some embodiments, an endoprosthesis includes a member including a bioerodible material, and an antioxidant carried by the member. Examples of antioxidants include phenols.

Bioerodible endoprostheses and methods of making the same

In one aspect, the present invention provides composite coatings for implantable or insertable medical devices. These composite coatings comprise (a) an inorganic portion and (b) a polymeric portion that comprises a poly(vinyl pyrrolidone) (PVP) block.

Polymeric/inorganic composite materials for use in medical devices

A therapeutic agent delivery device and method for eluting a therapeutic agent to a target location are disclosed. The therapeutic agent delivery device may comprise a first conductive element, a second conductive element, and an electrochemical layer including a neurotoxin located between the first conductive element and the second conductive element. The first conductive element and the second conductive element are adapted to be connected to a voltage source. When the first conductive element and the second conductive element are connected to the voltage source, an electrochemical reaction occurs causing the neurotoxin to release from the electroactive layer and elute to a target location.

Therapeutic agent delivery device for delivery of a neurotoxin

A bioerodible endoprosthesis erodes by galvanic erosion that can provide, e.g., improved endothelialization and therapeutic effects.

A stent includes a MOF which adjusts pore size upon desorption or adsorption of organic molecules.

Endoprosthesis

The present invention pertains, among other things, to polymers having one or more lipophilic hydrocarbon segments and one or more biodegradable polymeric segments, to methods of making such polymers and to products formed using such polymers.

Polymers having lipophilic hydrocarbon and biodegradable polymeric segments

A therapeutic agent delivery device and method for eluting a therapeutic agent to a target location are disclosed. The device may comprise a first conductive element, a second conductive element, an electrochemical composition including an electrolyte and a therapeutic agent, and a permeable membrane covering the electrochemical composition. The first conductive element and the second conductive element are adapted to be connected to a voltage source. When the voltage source is connected to the first conductive element and the second conductive element, an electrochemical reaction occurs causing the therapeutic agent to pass through the permeable membrane and thereby to elute to a target location.

Electrochemical therapeutic agent delivery device

The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents.

Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power

Radiopaque polymers have a main chain and a plurality of amide groups which have bound to the amide nitrogen atom thereof an organohalide group that is pendant to the polymer main chain, the organo halide group including one or more iodine and/or bromine atoms thereon. The polymer may be a modified polyamide polymer, copolymer or block copolymer or a modified poly(meth)acrylamide or (meth)acrylamide copolymer or block copolymer. The polymers may be employed in medical devices and are useful for instance to track the movement of a catheter through the body or the inflation of a balloon at a site. The polymers may be made by coupling reactions performed on preexisting amide polymers.

Radiopaque amide polymers and medical devices formed thereof

Growing community of inventors

Woodbury, MN, United States of America

Robert Warner