Corium International, Inc.

Corium Corporation

Corium Pharma Solutions, Inc.

Robert Wade Worsham

Parminder Singh

Guohua Chen

Joseph Creagan Trautman

Steven Richard Klemm

Danir F Bayramov

Danny Lee Bowers

Anthony Le

Ashutosh Shastry

Douglas Joseph Scott Bourne

Esi Ghartey-Tagoe

Andy Klemm

Zhongli Ding

Doug Bourne

Janet Wendorf

Andrew Richard Klemm

Steve Williams

Danir Bairamov

Danir Bayamov

Appala Sagi

Steven Richard Kelmm

Andy Kelmm

An applicator for a microprojection array is described. In one embodiment, the applicator comprises an energy-storing element. Application of force causes the compressed energy-storing element to extend or transition from first and second configurations, releasing stored energy to deploy a holding member in the application which is configured to hold an array of microprojections. In another embodiment, the applicator comprises an energy storing element with two stable configurations, a first stable configuration and second stable configuration. Application of force causes the energy-storing element to transition from the higher energy first stable configuration to the lower energy second stable configuration, releasing the difference in energies of the two states to deploy a holding member in the application which is configured to hold an array of microprojections.

Applicators for microneedles

A method and a drug delivery system for transdermally administering parathyroid hormone (PTH) in a pulsatile fashion are provided, where the drug delivery system comprises an array of microprojections each comprising PTH.

Method and device for transdermal delivery of parathyroid hormone using a microprojection array

Applicators for a microprojection array and methods of using the applicators are described.

Microprojection applicators and methods of use

Devices and methods for using and manufacturing microstructure arrays having at least a detachable distal area are described.

Microarray for delivery of therapeutic agent and methods of use

In an aspect of the invention, an array of microprotrusions is formed by providing a mold with cavities corresponding to the negative of the microprotrusions, casting atop the mold a first solution comprising a biocompatible material and a solvent, removing the solvent, casting a second solution atop the first cast solution, removing the solvent from the second solution, and demolding the resulting array from the mold. The first solution preferably contains an active ingredient.

Solvent-cast microprotrusion arrays containing active ingredient

Devices and methods for using and manufacturing microstructure arrays are described.

Microarray for delivery of therapeutic agent, methods of use, and methods of making

A microprojection array is provided, comprising an approximately planar base and a plurality of microprojections, wherein the array comprises a vaccine and a polymeric material. The array may have multiple layers. The vaccine may be placed in only one layer. In another embodiment of the invention, a method of preventing a disease is provided, comprising insertion into the skin of a patient an array of microprojections comprising a layer which comprises a vaccine for that disease and a polymer.

Method of vaccine delivery via microneedle arrays

Vaccine delivery via microneedle arrays

A microneedle applicator is provided which has two roughly concentric portions which may be, for example, a solid disk and an annulus surrounding it. On the skin-facing side of the inner portion of the applicator a microneedle array is located. The outer portion of the applicator is placed against the skin, contacting it at a zone. The microneedle array is then pressed towards the skin.

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Cupertino, CA, United States of America

Robert Wade Worsham