Biotheryx, Inc.

Other

Novomedix, LLC

Test-Um, Inc.

Sullstar Technologies, Inc.

Itherx Pharmaceuticals Inc.

Harris Corporation

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Nsi-Lynn Electronics, LLC

Robert W Sullivan

Leah M Fung

Kyle W H Chan

Frank Mercurio

Paul E Erdman

Eduardo Torres

Aparajita Hoskote Chourasia

Cathy A Swindlehurst

Imelda Lam

Antonio Garrido Montalban

Justin T Ernst

Edward Roberts

Christopher Larson

Lee Arthur Watkins

Russell Dahl

Hiroshi Nakanishi

Jeffrey Dean Kahl

Erik Boman

Susana Conde Ceide

Nancy G J Delaet

Eddine Saiah

Zhinjun Wang

David Aaron Hecht

Stephen F Miller

Fabrizio Mastronardi

Armen Manoukian

Sam Scanga

Joseph P Vacca

Wen-Lung Hung

Kenneth L McMahon

Kyle Wh Chan

Sara Howard

Kuan Yu Wang

Kyle WH Chan

Provided herein are phosphodiesterase 4 (PDE4) inhibitors, e.g., a compound of Formula (I) or (II), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a disease, disorder, or condition associated with PDE4 malfunction.

PDE4 inhibitors, pharmaceutical compositions, and therapeutic applications

Provided herein are non-hygroscopic crystalline salts of (1r,4r)-N-(5-chloro-4-(5-(cyclopropylmethyl)-1-methyl-1H-pyrazol-4-yl)pyrimidin-2-yl)cyclohexane-1,4-diamine and pharmaceutical compositions thereof. Also provided are methods of their use for treating, preventing, or ameliorating one or more symptoms of a proliferative disease.

Non-hygroscopic crystalline salts of a pyrazole compound, and pharmaceutical compositions and use thereof

An electrical connector, having an elongated plastic housing which is open at its rearward end and has an essentially continuous forward end wall with a flat upper portion, a lower portion of the forward end wall being integrally thickened to project forward beyond its upper portion.

Electrical connector with external load bar, and method of its use

Provided herein are substituted biaryl sulfonamide compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate initiation of protein translation. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.

Substituted biaryl sulfonamides and the use thereof

Compounds with amino amide linkers and pharmaceutical compositions and medicaments comprising such compounds are disclosed. In addition, methods of making such compounds and their uses for treating or ameliorating diseases, disorders, or conditions associated with protein malfunction, such as cancer, are provided.

Aminoamide compounds

Substituted isoindolinones of Formula (I), methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds to treat or ameliorate diseases, disorders, or conditions associated with protein malfunction, such as cancer, are provided. 

Substituted isoindolinones

The present invention provides compounds that modulate protein function, to restore protein homeostasis, including cytokine, CK1&#x3b1;, GSPT1, aiolos, and/or ikaros activity, and cell-cell adhesion. The invention provides methods of modulating protein-mediated diseases, such as cytokine-mediated diseases, disorders, conditions, or responses. Compositions, including in combination with other cytokine and inflammatory mediators, are provided. Methods of treatment, amelioration, or prevention of diseases, disorders, or conditions associated with a protein, such as diseases, disorders, and conditions associated with cytokines, including inflammation, fibromyalgia, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, psoriasis, psoriatic arthritis, inflammatory bowel diseases, Crohn's disease, ulcerative colitis, uveitis, inflammatory lung diseases, chronic obstructive pulmonary disease, Alzheimer's disease, and cancer, are provided.

Compounds targeting proteins, compositions, methods, and uses thereof

The present disclosure provides compounds, for example, a compound of Formula (I), that modulate a protein function and/or restore protein homeostasis. The disclosure provides a method of modulating a protein-mediated disease, disorder, condition, or response. Compositions, including in combination with other therapeutic agents, are provided. 

Protein-targeting compounds and pharmaceutical compositions thereof, and their therapeutic applications

The present invention provides compounds that modulate protein function, specifically phosphodiesterase 4 (PDE4). The invention provides methods of treating, ameliorating, and/or preventing diseases, disorders, and conditions associated with PDE4. Compositions, including in combination with other inflammatory mediators, are also provided.

Bicyclic compounds and methods of use

The present application provides compounds that modulate CDK protein function. Methods of making the compounds, compositions containing the compounds, and uses of the compounds for treating or ameliorating of diseases, disorders, or conditions associated with CDK proteins, are also disclosed.

Bifunctional compounds

The present disclosure provides compounds that modulate protein function, to restore protein homeostasis, and cell-cell adhesion. The disclosure provides methods of modulating protein-mediated diseases, such as cytokine-mediated diseases, disorders, conditions, or responses. Compositions, including in combination with other cytokine and inflammatory mediators, are provided. Methods of treatment, amelioration, or prevention of diseases, disorders, or conditions associated with a protein, are provided.

Fused thiophene compounds

A modular plug system including a plug housing including a top surface, bottom surface and two opposing side surfaces, a front end and an opening opposite the front end, and a cavity extending from the front end to the opening in the back end with a plurality of openings extending through the front surface to the cavity, a plurality of guide units in the cavity positioned such that each of a plurality of wires engages a respective guide unit, a cutting surface extending from a lower portion of the front end such that the cutting surface is below the lowest row of openings, where the cutting surface is sized to accommodate two pillars on a crimping device with the two pillars being positioned on opposing sides of the cutting surface when the tool engages the plug.

Provided herein are nitrite salts of 1,1-dimethylbiguanide; and isotopic variants thereof; and pharmaceutically acceptable hydrates and solvates thereof. Also provided herein are their pharmaceutical compositions and methods of use for treating, preventing, or ameliorating one or more symptoms of diseases associated with and/or caused by an abnormal blood glucose level. Further provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a cardiovascular disease.

Nitrite salts of 1,1-dimethylbiguanide, pharmaceutical compositions, and methods of use

The present invention provides compounds that modulate protein function, to restore protein homeostasis and/or cell-cell adhesion. The invention provides methods of modulating protein-mediated diseases, such as cytokine-mediated diseases, disorders, conditions, or responses. Compositions of these compounds are also provided. Methods of treatment, amelioration, or prevention of protein-mediated diseases, disorders, and conditions are also provided.

Ether compounds and uses thereof

Growing community of inventors

Vista, CA, United States of America

Robert W Sullivan