Lantheus Medical Imaging, Inc.

Robert W Siegler

Simon P Robinson

David C Onthank

Nhung Tuyet Nguyen

Tarakeshwar Vishwanath Anklekar

Charles Chester Van Kirk

Derek F Rhodes

Richard R Cesati

James F Castner

Dianne D Zdankiewicz

Enrico Mongeau

The invention provides, inter alia, improved lipid formulations used to generate lipid-encapsulated gas microspheres, and methods of their use.

Lipid-encapsulated gas microsphere compositions and related methods

Provided herein are improved methods for preparing phospholipid formulations including phospholipid UCA formulations.

Methods for making ultrasound contrast agents

Techniques for monitoring a pharmaceutical manufacturing process and making determinations regarding the release of radiopharmaceuticals to health care providers. A data processing system collects data across multiple batches of radiopharmaceuticals, across multiple entities, and/or across multiple stages of the manufacturing process, processes the data, and provides feedback to entities involved in the manufacturing process. In scenarios where quality assurance tests are conducted, data is collected from radiopharmaceutical products before they are shipped, and the data is analyzed to provide the recipients with an indication of whether the radiopharmaceutical products satisfy quality assurance standards. Techniques for analyzing information about a batch manufacturing process and, when a problem occurred during a manufacture of a batch, determining whether to continue to manufacture a next batch in time for delivering and administering to a patient. The detected problem may be investigated and remedied before or during the synthesis of the next batch.

Control system for radiopharmaceuticals

The present invention generally relates to methods and system for the synthesis of imaging agents, and precursors thereof. The methods may exhibit improved yields and may allow for the large-scale synthesis of imaging agents, including imaging agents comprising a radioisotope (e.g.,F). Various embodiments of the invention may be useful as sensors, diagnostic tools, and the like. In some cases, methods for evaluating perfusion, including myocardial perfusion, are provided. Synthetic methods of the invention have also been incorporated into an automated synthesis unit to prepare and purify imaging agents that comprise a radioisotope. In some embodiments, the present invention provides a novel methods and systems comprising imaging agent, including methods of imaging in a subject comprising administering a composition comprising imaging agentto a subject by injection, infusion, or any other known method, and imaging the area of the subject wherein the event of interest is located.

Methods and apparatus for synthesizing imaging agents, and intermediates thereof

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Chelmsford, MA, United States of America

Robert W Siegler