University of Washington

Phaserx, Inc.

Immunex Corporation

Genevant Sciences Gmbh

Fred Hutchinson Cancer Center

Robert W Overell

Allan Sachs Hoffman

Patrick S Stayton

Paul Hickok Johnson

Anthony Convertine

Anna S Gall

Craig L Duvall

Mary Gallagher Prieve

Charbel Diab

Priyadarsi De

Danielle Benoit

Amber E E Paschal

Scott M Henry

Sean D Monahan

Michael S DeClue

Amber E Paschal

Amber Ee Paschal

Phillip D Greenberg

Paul H Johnson

Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instauces, micellic assemblies provided herein are pH sensitive particles.

Micellic assemblies

Polymeric compounds having spatially controlled bioconjugation sites are described. Functionalization is achieved by selective &#x3c9;-terminal chain extension of polymer chains by radical polymerization, such as reversible addition-fragmentation chain transfer (RAFT) polymerization.

&#x3c9;-functionalized polymers, junction-functionalized block copolymers, polymer bioconjugates, and radical chain extension polymerization

Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instances, micellic assemblies provided herein are pH sensitive particles.

Omega-functionalized polymers, junction-functionalized block copolymers, polymer bioconjugates, and radical chain extension polymerization

Provided herein are multiblock copolymers, as well as micelles and therapeutic compositions thereof.

Multiblock copolymers

A composition for delivering an agent to a cell, comprising a bispecific affinity reagent and a pH-responsive, membrane destabilizing polymer. The bispecific affinity reagent may include a first affinity reagent covalently linked to a second affinity reagent, wherein the first affinity reagent binds to a molecule on the surface of a cell, and the second affinity reagent binds to an intracellular target.

Bispecific intracellular delivery vehicles

Compositions comprising a heterogeneous polymeric micelle and an agent (e.g., a polynucleotide) associated with the micelle are disclosed, together with methods for intracellular delivery of such agent.

Heterogeneous polymeric micelles for intracellular delivery

Provided herein are polymeric carriers suitable for the delivery of polynucleotides (e.g. oligonucleotides) and/or other therapeutic agents into a living cell.

Polymeric carrier

The present invention relates to cytotoxic T lymphocytes (CTLs) which have been converted to a helper T cell independent phenotype by introducing a recombinant expression vector encoding IL-1 receptor into the CTL. The resulting CTLs have the ability to grow or function independent of T cell help.

Method for producing T.sub.H -independent cytotoxic T lymphocytes

A new class of oncogenic retroviral vectors is disclosed which comprise at least two oncogenes and a heterologous DNA sequence, each of which is independently transcribed in an infected or transfected cell under the control of a separate transcriptional control sequence.

Growing community of inventors

Seattle, WA, United States of America

Robert W Overell