The University of North Carolina at Chapel Hill

Cell Microsystems, Inc.

Robert W McClellan

Nancy L Allbritton

Nicholas C Trotta

Steven C Gebhart

Peter Joseph Attayek

Paul Michael Armistead

Embodiments of the disclosed subject matter provide an automated method and system to isolate and collect cells using computerized analysis of images of cells and their surroundings obtained from a digital imaging device or system. Embodiments of the disclosed subject matter make use of a 'microwell array,' which can comprise a formed, elastomeric grid of indentations or “wells.” Many, most, or all of the wells in a microwell array can contain a releasable, microfabricated element, which can be referred to as a “raft.” Embodiments of the disclosed subject matter provide a system and method for cell collection that includes computerized identification and collection of rafts with isolated single cells or a specific group or groups of cells, eliminating the need for continuous human identification and selection.

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Apex, NC, United States of America

Robert W McClellan