Arch Oncology, Inc.

Other

Robert W Karr

Pamela T Manning

Juan C Almagro

Robyn Puro

Gerhard Johann Frey

Hwai Wen Chang

William A Frazier

Provided are anti-CD47 monoclonal antibodies (anti-CD47 mAbs) with distinct functional profiles as described herein, methods to generate anti-CD47 mAbs, and to methods of using these anti-CD47 mAbs as therapeutics for the prevention and treatment of solid and hematological cancers, ischemia-reperfusion injury, cardiovascular diseases, autoimmune diseases, inflammatory diseases or as diagnostics for determining the level of CD47 in tissue samples.

Therapeutic CD47 antibodies

Provided are monoclonal antibodies and antigen-binding fragments thereof that bind to, and inhibit the activity of, CD47, as well as monoclonal antibodies and antigen binding fragments thereof that compete with the former for binding to CD47. Also provided are combinations of any of the foregoing. Such antibody compounds are variously effective in 1) treating tissue ischemia and ischemic-reperfusion injury (IRI) in the setting of organ preservation and transplantation, pulmonary hypertension, sickle cell disease, myocardial infarction, stroke, and other instances of surgery and/or trauma in which IRI is a component of pathogenesis; 2) in treating autoimmune and inflammatory diseases; and 3) as anti-cancer agents that are toxic to susceptible cancer cells, promoting their phagocytic uptake and clearance, or directly killing such cells.

A bar puller for a numerically controlled turret lathe having a mounting member for mounting the bar puller to one of the stations of a rotary turret on the lathe, the bar puller having a pair of gripping jaws that are pivotally mounted between clevis plates on pivot pins and biased by a plurality of compression springs, the jaw blocks carrying adjustable gripping members that engage the end of a bar stock and draw the bar stock in the chuck on displacement of the turret carriage with the gripping jaws being released by further displacement of the turret carriage after a chuck has been secured on the stock.

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St. Louis, MO, United States of America

Robert W Karr